IAI CONFERENCE: Dissolution profile of Curcumin from solid dispersion prepared at a high drug load of Curcumin using Poloxamer 407 as the carrier
DOI:
https://doi.org/10.46542/pe.2021.212.7780Keywords:
BCS II, Bioavailability, Curcuma longa, Poloxamers, Rotary evaporatorAbstract
Introduction: Curcumin, a BCS II drug, suffers from poor bioavailability. Increasing curcumin dissolution is a way to increase its bioavailability. Solid dispersion formulation can be used to improve curcumin dissolution. However, the successful curcumin solid dispersion is limited to a relatively low drug load (< 20%).
Aim: This study aimed to investigate the dissolution behaviour of curcumin at a higher drug load (27.9%, 42.3%, and 56.6%) using a surfactant carrier of poloxamer 407.
Methods: The solvent evaporation method was employed to prepare high drug load solid dispersion of curcumin. A physical mixture of the corresponding solid dispersion formulation was prepared as a control. Drug load, dissolution behaviour in 180 minutes, and dissolution efficiency (DE180) were determined.
Results: The results showed that incorporating curcumin into a poloxamer 407 solid dispersion significantly improves the dissolution rate of curcumin. In the solid dispersion formula, the dissolution behaviour of curcumin was found to be carrier-dependent.
References
Abdollahi, E., Momtazi, A. A., Johnston, T. P., & Sahebkar, A. (2017). Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades? Journal of Cellular Physiology, https://doi.org/10.1002/jcp.25778
Ali, W., Williams, A. C., & Rawlinson, C. F. (2010). Stochiometrically governed molecular interactions in drug: Poloxamer solid dispersions. International Journal of Pharmaceutics, 391(1-2), 162-168. https://doi.org/10.1016/j.ijpharm.2010.03.014
Basnet, P., & Skalko-Basnet, N. (2011). Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules, 16(6), 4567-4598
Bodratti, A. M., & Alexandridis, P. (2018). Formulation of Poloxamers for Drug Delivery. Journal of Functional Biomaterials, 9(1), 11
Craig, D. Q. (2002). The mechanisms of drug release from solid dispersions in water-soluble polymers. International Journal of Pharmaceutics, 231(2), 131-144. https://doi.org/10.1016/s0378-5173(01)00891-2
Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2012). Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. The AAPS Journal, 15(1), 195-218
Leuner, C., & Dressman, J. (2000). Improving drug solubility for oral delivery using solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics, 50(1), 47-60
Wang, Y. J., Pan, M. H., Cheng, A. L., Lin, L. I., Ho, Y. S., Hsieh, C. Y., & Lin, J. K. (1997). Stability of curcumin in buffer solutions and characterization of its degradation products. Journal of Pharmaceutical and Biomedical Analysis, 15(12), 1867-1876
