IAI CONFERENCE: Fluconazole-tartaric acid co-crystal formation and its mechanical properties

Authors

  • Fikri Alatas Universitas Jenderal Achmad Yani, Indonesia
  • Nia Suwartiningsih Universitas Jenderal Achmad Yani, Indonesia
  • Hestiary Ratih Universitas Jenderal Achmad Yani, Indonesia
  • Titta Hartyana Sutarna Universitas Jenderal Achmad Yani, Indonesia

DOI:

https://doi.org/10.46542/pe.2021.212.116122

Keywords:

Flowability, Fluconazole, Tartaric acid, Mechanical properties, Ultrasound-assisted solution co-crystallisation (USSC), Tabletability

Abstract

Introduction: The formation of co-crystal is widely studied to obtain more favourable physicochemical properties than the pure active pharmaceutical ingredient (API). The co-crystal formation between an anti-fungal drug, fluconazole (FLU), and tartaric acid (TAR) has been investigated and its impact on mechanical properties has also been studied.    

Methods: The co-crystal of FLU-TAR (1:1) molar ratio was prepared by ultrasound-assisted solution co-crystallization (USSC) method with ethanol as the solvent. Polarization microscopy was used to observe the crystal morphology. Meanwhile, powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods were used to characterise the co-crystal formation. The mechanical properties of the co-crystal, such as flowability and tablet-ability, were compared with pure FLU. 

Results: Photomicroscopes revealed the unique crystal morphology of the USSC product was different from the two starting components. The typical PXRD pattern was shown by the USSC product, which indicated the formation of FLU-TAR co-crystal. In addition, the DSC thermogram revealed 169.2°C as the melting point of the FLU-TAR co-crystal, which is between the melting points of FLU and TAR. It indicates that FLU-TAR co-crystal has better flowability and tablet-ability than pure FLU.     

Conclusion: FLU-TAR co-crystal is one of the alternative solid forms for a raw material in pharmaceutical tablet preparation because it has better mechanical properties than pure fluconazole.

Author Biographies

Fikri Alatas, Universitas Jenderal Achmad Yani, Indonesia

Faculty of pharmacy

Nia Suwartiningsih, Universitas Jenderal Achmad Yani, Indonesia

Faculty of pharmacy

Hestiary Ratih, Universitas Jenderal Achmad Yani, Indonesia

Faculty of pharmacy

Titta Hartyana Sutarna , Universitas Jenderal Achmad Yani, Indonesia

Faculty of pharmacy

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Published

28-07-2021

How to Cite

Alatas, F. ., Suwartiningsih, N. ., Ratih, H. ., & Sutarna , T. H. . (2021). IAI CONFERENCE: Fluconazole-tartaric acid co-crystal formation and its mechanical properties. Pharmacy Education, 21(2), p. 116–122. https://doi.org/10.46542/pe.2021.212.116122

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Conference Proceedings