IAI CONFERENCE: The potential effect of the green coffee extract on reducing atherogenic index in hyperlipidemic rats
DOI:
https://doi.org/10.46542/pe.2021.212.126131Keywords:
Atherogenic index, Cardiac histopathology, Green coffee extractAbstract
Introduction: Dyslipidemia is a risk factor for atherosclerosis and cardiovascular disease. The high prevalence of dyslipidemia triggers the development of green coffee supplement products, which are claimed as cholesterol-lowering and slimming agents. Nonetheless, research data on the effect of taking green coffee supplement products, especially regarding cardiovascular function, is limited.
Aims: To determine the potential effect of green coffee extract (GCE) on improving atherogenic index of plasma (AIP) and cardiac histopathology in hyperlipidemic rats.
Methods: 24 rats were induced by high-fat feed for 21 days. Then, the rats were treated with a GCE, dose of 200, 400, and 800 mg/kg bodyweight for 14 days. The next day, blood was collected from the rats to take measurements of their serum lipid profile and calculating their AIP. The heart organ was created by using histopathological preparations.
Results: Administration of GCE in all doses significantly reduced the AIP and improved cardiac histopathology in the hyperlipidemic rats.
Conclusions: GCE can be developed as a cardio-protector.
References
Akila, P., Asaikumar, L., & Vennila, L. (2017). Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes. Biomed Pharmacother, 85, 582-591
Aziz, Z., Cyriac, S., Beena, V., & Philomina, P.T. (2012). Comparison of cholesterol content in chicken, duck and quail eggs. Journal of Veterinary Animal Sciences, 43, 64-66
Bhandarkar, S.N., Brown, L., & Panchal, S.K. (2019). Chlorogenic acid attenuates high-carbohydrate, high-fat diet–induced cardiovascular, liver, and metabolic changes in rats. Nutrition Research, 62, 78-88
Bhandarkar, S.N., Mouatt, P., Brown, L., & Panchal, S.K. (2019). Green coffee ameliorates components of diet-induced metabolic syndrome in rats. Journal of Functional Foods, 57, 141-149
Bhardwaj, S., Bhattacharjee, J., Bhatnagar, M.K., & Tyagi, S. (2013). Atherogenic index of plasma, Castelli risk index and atherogenic coefficient - New parameters in assessing cardiovascular risk. International Journal of Pharmacy and Biological Science, 3(3), 359-364
Choi, B.K., Park, S.B., Lee, D.R., Lee, H.J., Jin, Y.Y., Yang, S.H., & Sub, W.H. (2016). Green coffee bean extract improves obesity by decreasing body fat in high-fat-diet induced obese mice. Asian Pacific Journal of Tropical Medicine, 9(7), 635-643
Christianty, F.M., Holidah, D., Fajrin, F.A., Salsabina, M.C.A., & Roni, A. (2020). The lipid profile and aorta histopathology on hyperlipidemic rat by giving green coffee extract. Jurnal Ilmu Kefarmasian Indonesia, 18(1), 21-27
DiPiro, J.T., Wells, B.G., Schwinghammer, T.L., & DiPiro, C.V. (2014). Pharmacotherapy Handbook (pp. 712-756). New York, USA: McGraw-Hill Education Companies
Dobiasova, M. (2004). Atherogenic index of plasma [log(triglycerides/HDL-cholesterol)]: theoretical and practical implications. Clin Chem, 50(7), 1113–1115
Dwiloka, B. (2003). Efek kolesterolemik berbagai telur. Media Gizi dan Keluarga, 27(2), 58-65
Farah, A. (2012). Coffee Constituents in Coffee: Emerging Health Effects and Disease Revention. United Kingdom: Blackwell Publishing Ltd
Frohlich, J. & Dobiasova, M. (2003). Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography. Clinical Chemistry, 49(11), 1873–1880
Ji, L., Jiang, P., Lu, B., Sheng, Y., Wang, X., & Wang, Z. (2013). Chlorogenic acid, a dietary polyphenol, protects acetaminopheninducted liver injury and its mechanism. Journal of Nutritional Biochemistry, 24(11), 1911-1919
Kapourchali, F.R., Surendiran, G., Chen, L., Ultz, E., Bahadori, B., & Moghadasian, M.H. (2014). Animal model of atherosclerosis. World Journal of Clinical Cases, 2(5), 126–132
Khazaál, M.S. (2013). Atherogenic index of plasma (AIP) as a parameter in predicting cardiovascular risk in males compared to the conventional dyslipidemic indices (cholesterol ratios). Karbala Journal of Medicine, 6(1), 1-8
Lembaga Ilmu Pengetahuan Indonesia (LIPI). (2009). Kolesterol, Pangan dan Kesehatan. Bandung: UPT-Balai Informasi Teknologi
Li, S.Y., Chang, C.Q., Ma, F.Y., & Yu, C.L. (2009). Modulating effects of chlorogenic acid on lipids and glucose metabolism and expression of hepatic peroxisome proliferator-activated receptor-α in golden hamsters fed on high fat diet. Biomedical Environmental Science, 22(2), 122-129
Meng, S., Cao, J., Feng, Q., Peng, & Hu, Y. (2013). Roles of chlorogenic acid on regulating glucose and lipids metabolism: A Review. Journal of Evidence Based Complementary Alternative Medicine, 2013, 1-11
Ministry of Agriculture, Republic of Indonesia. (2016). Statistik Perkebunan Indonesia 2015-2017: Kopi. Jakarta: Sekretariat Direktorat Jenderal Perkebunan, Directorate General of Plantation, Ministry of Agriculture
Ministry of Health, Republic of Indonesia. (2013). Riset Kesehatan Dasar 2013. Jakarta: Balitbang, Ministry of Health, Republic of Indonesia
Nelson, R.H. (2013). Hyperlipidemia as a risk factor for cardiovascular disease. Primary Care, 40(1), 195-211
Niroumand, S., Khajedaluee, M., Rezaiyan, M.K., Abrishami, M., Juya, M., Khodaee, G., & Dadgarmoghaddam, M. (2015). Atherogenic index of plasma (AIP): a marker of cardiovascular disease. Medical Journal of the Islamic Republic of Iran, 29(240), 1-9
Nurfadilah, Nurainiwati, S.A., & Agustini, S.M. (2013). Pengaruh pemberian minyak deep frying terhadap perubahan histopatologi jantung tikus putih (Rattus novergicus strain Wistar). Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga, 9(1), 1-5
Ong, K.W., Hsu, A., & Tan, B.K.H. (2013). Antidiabetic and anti-lipidemic effects of chlorogenic acid are mediated by AMPK activation. Biochemical Pharmacology, 85(9), 1341-1351
Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI). (2013). Pedoman Tata Laksana Dislipidemia. Jakarta: Centra Communications
Rodwell, V.W., Bender, D.A., Botham, K.M., Kennelly, P.J., & Weil, P.A. (2018) Harper’s Illustrated Biochemistry, 31th edition. New York: McGraw-Hill Education
Sato, Y., Itagaki, S., Kurokawa, T., Ogura, J., Kobayashi, M., Hirano, T., Sugarawa, M., & Iseki, K. (2011). In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. International Journal of Pharmaceutics, 403(1-2), 136-138
Setyono, J., Nugroho, D.A., Mustofa, & Saryono. (2014). Efek orlistat, ekstrak biji kopi hijau, dan kombinasinya terhadap kadar adiponektin dan profil lipid. Jurnal Ners, 9(1), 26–34
Shimoda, H., Seki, E., & Aitani, M. (2006). Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complementary Alternative Medicine, 6(9), 1-9
Walker, R. & Whittlesea, C. (2012). Clinical Pharmacy and Therapeutics, 5th edition. United Kingdom: Elsevier
Wan, C.W., Wong, C.N.Y., Pin, W.K., Wong, M.H.Y., Kwok, C.Y., Chan, R.Y.K., & Chan, S.W. (2012). Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. Phytotherapy Research, 27(4), 545–551. https://doi.org/10.1002/ptr.4751
WHO. (2012). Reducing Risks, Promoting Healthy Life: The World Health Report. Switzerland: WHO
