IAI CONFERENCE: The therapeutic outcomes and adverse drug reactions study of Clozapine on Schizophrenia inpatients in the Grhasia psychiatric hospital Yogyakarta, Indonesia

DOI:

https://doi.org/10.46542/pe.2021.212.287295

Keywords:

Adverse drug reaction, Clozapine, Schizophrenia, Therapeutic outcome

Abstract

Introduction: Clozapine is an antipsychotic agent used in schizophrenia recurrence or when other antipsychotics are not effective.   

Aims: This study aims to determine the therapeutic outcome and adverse drug reactions of clozapine in schizophrenia disorder among hospitalised patients.   

Methods: A retrospective cross-sectional study was conducted between January 2018 and December 2019 using inpatients’ medical records from the Grhasia Psychiatric Hospital, Yogyakarta. The therapeutic outcome was measured with the PANSS-EC scale, while adverse drug reactions of clozapine were analysed theoretically as per the literature. 

Results: The average decrease in the PANSS-EC score was 8.27, and the average duration to achieve this decrease was 2.5 days. The combination of typical-atypical antipsychotics could reduce the highest PANSS-EC score of 11-15 (41%). The adverse drug reactions of clozapine were tremor, weight gain, obesity, leucopenia, hyperglycemia, and hypercholesterolemia, among other effects.

Conclusion: Clozapine is effective in improving positive and negative symptoms, but its use needs close monitoring.

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Published

28-07-2021

How to Cite

IAI CONFERENCE: The therapeutic outcomes and adverse drug reactions study of Clozapine on Schizophrenia inpatients in the Grhasia psychiatric hospital Yogyakarta, Indonesia . (2021). Pharmacy Education, 21(2), p. 287–295. https://doi.org/10.46542/pe.2021.212.287295

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Conference Proceedings