IAI SPECIAL EDITION: The potential of Mimosa pudica L as an α- glucosidase inhibitor and antioxidant agent

Authors

DOI:

https://doi.org/10.46542/pe.2022.222.14

Keywords:

Antidiabetic, Antioxidant, Mimosa pudica

Abstract

Background: The putri malu plant (Mimosa pudica L.) is a South American and Central American native widely distributed throughout Indonesia. Indonesians utilise this plant as a herbal treatment to treat various ailments, including insomnia, acute eye inflammation, stone pee, fever, worms, bronchitis, and herpes.   

Objectives: This plant was studied for its antioxidant and α-glucosidase inhibitory activities using n-hexane, dichloromethane, ethyl acetate, and water extracts.    

Method: The aerial part of the plant was extracted with methanol and partitioned with n-hexane, dichloromethane (DCM), and ethyl acetate to obtain n-hexane (EHMP) dichloromethane (EDMP), ethyl acetate (EEMP), and water (EAMP) extracts. All extracts were analysed for their α-glucosidase inhibitor and antioxidants with the free radical scavenging activity method using DPPH.    

Results: EAMP showed antidiabetic activity with inhibition of 69.9% at a concentration of 500 ppm, and other extracts showed no α-glucosidase inhibition activity. For antioxidant activity, EDMP, EEMP, and EAMP showed relatively high activity with IC50 consecutively 77.4 ppm, 26.9 ppm, and 81.4 ppm, while EHMP had a reasonably low activity with IC50 635.6 ppm.   

Conclusion: The study results showed that M. pudica has considerable potential as a source of antidiabetics and natural antioxidants, so it is necessary to isolate secondary metabolites from the species.

Author Biographies

Muhamad Afham, Universitas Riau, Pekanbaru, Riau, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Sciences

Hilwan Yuda Teruna, Universitas Riau, Pekanbaru, Riau, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Sciences

Rudi Hendra, Universitas Riau, Pekanbaru, Riau, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Sciences

References

Amalraj, T., & Ignacimuthu, S. (2002). Hyperglycemic effect of leaves of Mimosa pudica Linn. Fitoterapia, 73(4), 351-352

Arokiyaraj, S., Sripriya, N., Bhagya, R., Radhika, B., Prameela, L., & Udayaprakash, N. (2012). Phytochemical screening, antibacterial and free radical scavenging effects of Artemisia nilagirica, Mimosa pudica and Clerodendrum siphonanthus–An in–vitro study. Asian Pacific Journal of Tropical Biomedicine, 2(2), S601-S604

Basha, B., Samuel, S.M., Triggle, C.R., & Ding, H. (2012). Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Experimental diabetes research, 2012 https://doi.org/10.1155/2012/481840

Baynes, H.W. (2015). Classification, pathophysiology, diagnosis and management of diabetes mellitus. Journal of diabetes metabolism, 6(5), 1-9. https://doi.org/10.4172/2155-6156.1000541

Chowdhury, S.A., Islam, J., Rahaman, M.M., Rahman, M. M., Rumzhum, N.N., Sultana, R., & Parvin, M.N. (2008). Cytotoxicity, antimicrobial and antioxidant studies of the different plant parts of Mimosa pudica. Stamford journal of pharmaceutical sciences, 1(1), 80-84

El Ridhasya, F., Rahim, N., Almurdani, M., Hendra, R., & Teruna, H.Y. (2020). Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacognosy Journal, 12(2)

Folli, F., Corradi, D., Fanti, P., Davalli, A., Paez, A., Giaccari, A., Perego, C., & Muscogiuri, G. (2011). The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Current diabetes reviews, 7(5), 313-324. https://doi.org/10.2174/157339911797415585

Hasimu, P., & Adnyana, K. (2019). a-Glucosidase activity: Implication for Diabetes In R. R. Watson & V. R. Preedy (Eds.), Bioactive Food as Dietary Interventions for Diabettes (pp. 387-393). United Kingdom: elsevier

Hendra, R., Gurning, S.N., Panjaitan, U.P.A., & Teruna, H.Y. (2020). Antioxidant activity of an Epiphyte Fern in Palm Oil Tree. Paper presented at the Journal of Physics: Conference Series

Hendra, R., & Keller, P.A. (2017). Phytochemical studies on two Australian Anigozanthos plant species. Journal of Natural Products, 80(7), 2141-2145

Hendra, R., Masdeatresa, L., Abdulah, R., & Haryani, Y. (2020). Red dragon peel (Hylocereus polyrhizus) as antioxidant source. Paper presented at the AIP Conference Proceedings

Hirano, R., Sasamoto, W., Matsumoto, A., Itakura, H., Igarashi, O., & Kondo, K. (2001). Antioxidant ability of various flavonoids against DPPH radicals and LDL oxidation. Journal of Nutritional Science and Vitaminology, 47(5), 357-362

Kupchan, S., Shizuri, Y., Murae, T., Sweeny, J., Haynes, H., Shen, M., Barrick, J.C., Bryan, R.F., der Helm, D.V., & Wu, K.K. (1976). Gnidimacrin and Gnidimacrin-20-palmitate, novel macrocyclic anti-leukemic diterpenoid esters from Gnidia subcordata. Journal of the American Chemical Society, 98, 5719-5720

Lakshamibai, R., & Amirtham, D. (2018). Evaluation of Free Radical Scavening Activity of Mimosa Pudica Thorns. Asian Journal of Pharmaceutical and Clinical Research, 11(11), 153-156

Muhammad, G., Hussain, M.A., Jantan, I., & Bukhari, S. N. A. (2016). Mimosa pudica L., a high‐value medicinal plant as a source of bioactives for pharmaceuticals. Comprehensive Reviews in Food Science and Food Safety, 15(2), 303-315

Sarian, M.N., Ahmed, Q.U., Mat So’ad, S.Z., Alhassan, A. M., Murugesu, S., Perumal, V., Mohamad, S.N.A.S., Khatib, A., & Latip, J. (2017). Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study. BioMed Research International, 2017, https://doi.org/10.1155/2017/8386065

Sunday, R.M. (2020). Antioxidant and Antidiabetic Properties of Mimosa pudica Seeds in Streptozotocin-induced Diabetic Wistar Rats. Asian Journal of Biotechnology, 12, 1-8

Tasnuva, S., Qamar, U., Ghafoor, K., Sahena, F., Jahurul, M., Rukshana, A., Juliana, M.J., Al-Juhaimi, F.Y., Jalifah, L., Jalal, K.C.A., Ali, M.E., Zaidul, I.S.M. (2019). α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research, 33(10), 1495-1499

Tunna, T., Zaidul, I., Ahmed, Q., Ghafoor, K., Al-Juhaimi, F., Uddin, M.S., Hasan, M., & Ferdous, S. (2015). Analyses and profiling of extract and fractions of neglected weed Mimosa pudica Linn. traditionally used in Southeast Asia to treat diabetes. South African Journal of Botany, 99, 144-152

Downloads

Published

2022-03-31

How to Cite

Afham, M. ., Teruna, H. Y. ., & Hendra, R. (2022). IAI SPECIAL EDITION: The potential of Mimosa pudica L as an α- glucosidase inhibitor and antioxidant agent . Pharmacy Education, 22(2), p. 1–4. https://doi.org/10.46542/pe.2022.222.14

Issue

Section

Special Edition