IAI SPECIAL EDITION: The potential of Mimosa pudica L as an α- glucosidase inhibitor and antioxidant agent
Keywords:Antidiabetic, Antioxidant, Mimosa pudica
Background: The putri malu plant (Mimosa pudica L.) is a South American and Central American native widely distributed throughout Indonesia. Indonesians utilise this plant as a herbal treatment to treat various ailments, including insomnia, acute eye inflammation, stone pee, fever, worms, bronchitis, and herpes.
Objectives: This plant was studied for its antioxidant and α-glucosidase inhibitory activities using n-hexane, dichloromethane, ethyl acetate, and water extracts.
Method: The aerial part of the plant was extracted with methanol and partitioned with n-hexane, dichloromethane (DCM), and ethyl acetate to obtain n-hexane (EHMP) dichloromethane (EDMP), ethyl acetate (EEMP), and water (EAMP) extracts. All extracts were analysed for their α-glucosidase inhibitor and antioxidants with the free radical scavenging activity method using DPPH.
Results: EAMP showed antidiabetic activity with inhibition of 69.9% at a concentration of 500 ppm, and other extracts showed no α-glucosidase inhibition activity. For antioxidant activity, EDMP, EEMP, and EAMP showed relatively high activity with IC50 consecutively 77.4 ppm, 26.9 ppm, and 81.4 ppm, while EHMP had a reasonably low activity with IC50 635.6 ppm.
Conclusion: The study results showed that M. pudica has considerable potential as a source of antidiabetics and natural antioxidants, so it is necessary to isolate secondary metabolites from the species.
Amalraj, T., & Ignacimuthu, S. (2002). Hyperglycemic effect of leaves of Mimosa pudica Linn. Fitoterapia, 73(4), 351-352
Arokiyaraj, S., Sripriya, N., Bhagya, R., Radhika, B., Prameela, L., & Udayaprakash, N. (2012). Phytochemical screening, antibacterial and free radical scavenging effects of Artemisia nilagirica, Mimosa pudica and Clerodendrum siphonanthus–An in–vitro study. Asian Pacific Journal of Tropical Biomedicine, 2(2), S601-S604
Basha, B., Samuel, S.M., Triggle, C.R., & Ding, H. (2012). Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Experimental diabetes research, 2012 https://doi.org/10.1155/2012/481840
Baynes, H.W. (2015). Classification, pathophysiology, diagnosis and management of diabetes mellitus. Journal of diabetes metabolism, 6(5), 1-9. https://doi.org/10.4172/2155-6156.1000541
Chowdhury, S.A., Islam, J., Rahaman, M.M., Rahman, M. M., Rumzhum, N.N., Sultana, R., & Parvin, M.N. (2008). Cytotoxicity, antimicrobial and antioxidant studies of the different plant parts of Mimosa pudica. Stamford journal of pharmaceutical sciences, 1(1), 80-84
El Ridhasya, F., Rahim, N., Almurdani, M., Hendra, R., & Teruna, H.Y. (2020). Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacognosy Journal, 12(2)
Folli, F., Corradi, D., Fanti, P., Davalli, A., Paez, A., Giaccari, A., Perego, C., & Muscogiuri, G. (2011). The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Current diabetes reviews, 7(5), 313-324. https://doi.org/10.2174/157339911797415585
Hasimu, P., & Adnyana, K. (2019). a-Glucosidase activity: Implication for Diabetes In R. R. Watson & V. R. Preedy (Eds.), Bioactive Food as Dietary Interventions for Diabettes (pp. 387-393). United Kingdom: elsevier
Hendra, R., Gurning, S.N., Panjaitan, U.P.A., & Teruna, H.Y. (2020). Antioxidant activity of an Epiphyte Fern in Palm Oil Tree. Paper presented at the Journal of Physics: Conference Series
Hendra, R., & Keller, P.A. (2017). Phytochemical studies on two Australian Anigozanthos plant species. Journal of Natural Products, 80(7), 2141-2145
Hendra, R., Masdeatresa, L., Abdulah, R., & Haryani, Y. (2020). Red dragon peel (Hylocereus polyrhizus) as antioxidant source. Paper presented at the AIP Conference Proceedings
Hirano, R., Sasamoto, W., Matsumoto, A., Itakura, H., Igarashi, O., & Kondo, K. (2001). Antioxidant ability of various flavonoids against DPPH radicals and LDL oxidation. Journal of Nutritional Science and Vitaminology, 47(5), 357-362
Kupchan, S., Shizuri, Y., Murae, T., Sweeny, J., Haynes, H., Shen, M., Barrick, J.C., Bryan, R.F., der Helm, D.V., & Wu, K.K. (1976). Gnidimacrin and Gnidimacrin-20-palmitate, novel macrocyclic anti-leukemic diterpenoid esters from Gnidia subcordata. Journal of the American Chemical Society, 98, 5719-5720
Lakshamibai, R., & Amirtham, D. (2018). Evaluation of Free Radical Scavening Activity of Mimosa Pudica Thorns. Asian Journal of Pharmaceutical and Clinical Research, 11(11), 153-156
Muhammad, G., Hussain, M.A., Jantan, I., & Bukhari, S. N. A. (2016). Mimosa pudica L., a high‐value medicinal plant as a source of bioactives for pharmaceuticals. Comprehensive Reviews in Food Science and Food Safety, 15(2), 303-315
Sarian, M.N., Ahmed, Q.U., Mat So’ad, S.Z., Alhassan, A. M., Murugesu, S., Perumal, V., Mohamad, S.N.A.S., Khatib, A., & Latip, J. (2017). Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study. BioMed Research International, 2017, https://doi.org/10.1155/2017/8386065
Sunday, R.M. (2020). Antioxidant and Antidiabetic Properties of Mimosa pudica Seeds in Streptozotocin-induced Diabetic Wistar Rats. Asian Journal of Biotechnology, 12, 1-8
Tasnuva, S., Qamar, U., Ghafoor, K., Sahena, F., Jahurul, M., Rukshana, A., Juliana, M.J., Al-Juhaimi, F.Y., Jalifah, L., Jalal, K.C.A., Ali, M.E., Zaidul, I.S.M. (2019). α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research, 33(10), 1495-1499
Tunna, T., Zaidul, I., Ahmed, Q., Ghafoor, K., Al-Juhaimi, F., Uddin, M.S., Hasan, M., & Ferdous, S. (2015). Analyses and profiling of extract and fractions of neglected weed Mimosa pudica Linn. traditionally used in Southeast Asia to treat diabetes. South African Journal of Botany, 99, 144-152