IAI SPECIAL EDITION: The potential of Mimosa pudica L as an α- glucosidase inhibitor and antioxidant agent
DOI:
https://doi.org/10.46542/pe.2022.222.14Keywords:
Antidiabetic, Antioxidant, Mimosa pudicaAbstract
Background: The putri malu plant (Mimosa pudica L.) is a South American and Central American native widely distributed throughout Indonesia. Indonesians utilise this plant as a herbal treatment to treat various ailments, including insomnia, acute eye inflammation, stone pee, fever, worms, bronchitis, and herpes.
Objectives: This plant was studied for its antioxidant and α-glucosidase inhibitory activities using n-hexane, dichloromethane, ethyl acetate, and water extracts.
Method: The aerial part of the plant was extracted with methanol and partitioned with n-hexane, dichloromethane (DCM), and ethyl acetate to obtain n-hexane (EHMP) dichloromethane (EDMP), ethyl acetate (EEMP), and water (EAMP) extracts. All extracts were analysed for their α-glucosidase inhibitor and antioxidants with the free radical scavenging activity method using DPPH.
Results: EAMP showed antidiabetic activity with inhibition of 69.9% at a concentration of 500 ppm, and other extracts showed no α-glucosidase inhibition activity. For antioxidant activity, EDMP, EEMP, and EAMP showed relatively high activity with IC50 consecutively 77.4 ppm, 26.9 ppm, and 81.4 ppm, while EHMP had a reasonably low activity with IC50 635.6 ppm.
Conclusion: The study results showed that M. pudica has considerable potential as a source of antidiabetics and natural antioxidants, so it is necessary to isolate secondary metabolites from the species.
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