IAI SPECIAL EDITION: The potential of Mimosa pudica L as an α- glucosidase inhibitor and antioxidant agent





Antidiabetic, Antioxidant, Mimosa pudica


Background: The putri malu plant (Mimosa pudica L.) is a South American and Central American native widely distributed throughout Indonesia. Indonesians utilise this plant as a herbal treatment to treat various ailments, including insomnia, acute eye inflammation, stone pee, fever, worms, bronchitis, and herpes.   

Objectives: This plant was studied for its antioxidant and α-glucosidase inhibitory activities using n-hexane, dichloromethane, ethyl acetate, and water extracts.    

Method: The aerial part of the plant was extracted with methanol and partitioned with n-hexane, dichloromethane (DCM), and ethyl acetate to obtain n-hexane (EHMP) dichloromethane (EDMP), ethyl acetate (EEMP), and water (EAMP) extracts. All extracts were analysed for their α-glucosidase inhibitor and antioxidants with the free radical scavenging activity method using DPPH.    

Results: EAMP showed antidiabetic activity with inhibition of 69.9% at a concentration of 500 ppm, and other extracts showed no α-glucosidase inhibition activity. For antioxidant activity, EDMP, EEMP, and EAMP showed relatively high activity with IC50 consecutively 77.4 ppm, 26.9 ppm, and 81.4 ppm, while EHMP had a reasonably low activity with IC50 635.6 ppm.   

Conclusion: The study results showed that M. pudica has considerable potential as a source of antidiabetics and natural antioxidants, so it is necessary to isolate secondary metabolites from the species.

Author Biographies

Muhamad Afham, Universitas Riau, Pekanbaru, Riau, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Sciences

Hilwan Yuda Teruna, Universitas Riau, Pekanbaru, Riau, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Sciences

Rudi Hendra, Universitas Riau, Pekanbaru, Riau, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Sciences


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How to Cite

Afham, M. ., Teruna, H. Y. ., & Hendra, R. (2022). IAI SPECIAL EDITION: The potential of Mimosa pudica L as an α- glucosidase inhibitor and antioxidant agent . Pharmacy Education, 22(2), p. 1–4. https://doi.org/10.46542/pe.2022.222.14



Special Edition