IAI SPECIAL EDITION: α-Glucosidase inhibitory activities of Loranthus ferrugineus and Peperomia pellucida extracts
DOI:
https://doi.org/10.46542/pe.2022.222.58Keywords:
α-Glucosidase inhibitor, Loranthus ferrugineus, Peperomia pellucida, Traditional medicineAbstract
Introduction: The usage of traditional medicines in Indonesia has recently increased following the rise in regional COVID-19 cases. They were used to alleviate the symptoms of patients with pre-existing condition such as heart diseases, diabetes mellitus, and inflammation. They were also used to boost peoples immune system. Loranthus ferrugineus (Loranthaceae) and Peperomia pellucida (Piperaceae) were two medicinal plants used as anti-diabetes drugs.
Aim: This study aimed to measure the anti-diabetic activity of extracts of L. ferrugineus branches and the aerial parts of P. pellucida.
Method: Dried branches of L. ferrugineus were macerated using n-hexane, ethyl acetate, and methanol, respectively. Fresh aerial parts of P. pellucida were macerated with methanol and reduced the volume in vacuo. The extract was fractionated with n-hexane and ethyl acetate. These extracts and its fractions were dried and tested in vitro with α-glucosidase.
Results: α-Glucosidase inhibitory activities of ethyl acetate and methanol of L. ferrugineus were 89.21% and 92.98% at 500 ppm. However, there was no significant activity detected for the n-hexane extract. α-Glucosidase inhibitory activities of methanol extract, and its n-hexane and ethyl acetate fractions of P. pellucida were 8.26%, 0.83% and 28.19% at 500 ppm.
Conclusion: The methanol extract of L. ferrugineus and the ethyl acetate extract of L. ferrugineus are considered to have potential to be developed further as therapeutics.
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