IAI SPECIAL EDITION: The impact of mobile application: "Friends of Heart" in knowledge and compliance of patients with coronary heart disease


  • Riyan Pratama Putra University of Surabaya, Indonesia
  • Ike Dhiah Rochmawati University of Surabaya, Indonesia https://orcid.org/0000-0002-2497-7399
  • Delta Ardy Prima University of Surabaya, Indonesia




Adherence, Health mobile application, Knowledge


Background: The quality of life of coronary heart disease (CHD) patients can be improved by increasing patient compliance with treatment and health literacy rates. Over the past decade, mobile health (mHealth) has improved treatment adherence and demonstrated strong potential to increase health literacy rates.  

Objectives:  Analyse the effect of “Friends of Heart” application on the compliance and knowledge of coronary heart disease patients.   

Methods: A randomised controlled trial (RCT) was conducted. The test group (intervention group) used the Sahabat Jantung/ “Friends of Heart” application developed for the Android 4.1 operating system, while the control group did not. Compliance was measured for 30 days in outpatient settings; it included pill count and time deviations in taking medication. Knowledge was assessed using questionnaires.

Results: Statistical results showed significant differences in knowledge and adherence between the intervention and the control group (p = 0.0001). 

Conclusion:  The use of the “Friends of Heart” application could improve compliance and knowledge of coronary heart disease patients.

Author Biographies

Riyan Pratama Putra, University of Surabaya, Indonesia

Faculty of Pharmacy

Ike Dhiah Rochmawati, University of Surabaya, Indonesia

Department of Clinical and Community Pharmacy

Delta Ardy Prima, University of Surabaya, Indonesia

Programme of Informatics Engineering, Faculty of Engineering


Anderson, T.J., Grégoire, J., Pearson, G.J., Barry, A.R., Couture, P., Dawes, M., Francis, G.A., Genest, J., Jr, Grover, S., Gupta, M., Hegele, R.A., Lau, D.C., Leiter, L.A., Lonn, E., Mancini, G.B., McPherson, R., Ngui, D., Poirier, P., Sievenpiper, J.L., Stone, J.A., Thanassoulis, G., Ward, R. (2016). 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. The Canadian journal of cardiology, 32(11), 1263–1282. https://doi.org/10.1016/j.cjca.2016.07.510

Anghel, L.A., Farcas, A.M., & Oprean, R.N. (2019). An overview of the common methods used to measure treatment adherence. Medicine and pharmacy reports, 92(2), 117–122. https://doi.org/10.15386/mpr-1201

Bots, S.H., Peters, S., & Woodward, M. (2017). Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010. BMJ global health, 2(2), e000298. https://doi.org/10.1136/bmjgh-2017-000298

Chen, S., Gong, E., Kazi, D.S., Gates, A.B., Bai, R., Fu, H., Peng, W., De La Cruz, G., Chen, L., Liu, X., Su, Q., Girerd, N., Karaye, K.M., Alhabib, K.F., Yan, L.L., & Schwalm, J.D. (2018). Using Mobile Health Intervention to Improve Secondary Prevention of Coronary Heart Diseases in China: Mixed-Methods Feasibility Study. The Journal of Medical Internet Research, 6(1), e9. https://doi.org/10.2196/mhealth.7849

Developers, A. (2015) Mengenal Android Studio | Developer Android | Android Developers. Available at: https://developer.android.com/studio/intro?hl=ID

Fodor, J.G., & Tzerovska, R. (2004). Coronary heart disease: Is gender important? The Journal of Men's Health & Gender, 1(1), 32–37. https://doi.org/10.1016/j.jmhg.2004.03.005

Fröhlich, S.E., Dal Pizzol, T., & Mengue, S.S. (2010). Instrument to evaluate the level of knowledge about prescription in primary care. Revista de saude publica, 44(6), 1046–1054. https://doi.org/10.1590/s0034-89102010000600009

Guo, Y., Chen, Y., Lane, D.A., Liu, L., Wang, Y., & Lip, G. (2017). Mobile Health Technology for Atrial Fibrillation Management Integrating Decision Support, Education, and Patient Involvement: mAF App Trial. The American journal of medicine, 130(12), 1388–1396.e6. https://doi.org/10.1016/j.amjmed.2017.07.003

Jamee, A., Abed, Y., & Jalambo, M.O. (2013). Gender difference and characteristics attributed to coronary artery disease in Gaza-Palestine. Global journal of health science, 5(5), 51–56. https://doi.org/10.5539/gjhs.v5n5p51

Kini, V., & Ho, P.M. (2018). Interventions to Improve Medication Adherence: A Review. Journal of the American Medical Association, 320(23), 2461–2473. https://doi.org/10.1001/jama.2018.19271

Lam, W.Y., & Fresco, P. (2015). Medication Adherence Measures: An Overview. BioMed research international, 2015, 217047. https://doi.org/10.1155/2015/217047

Maas, A.H., & Appelman, Y.E. (2010). Gender differences in coronary heart disease. Netherlands heart journal, 18(12), 598–602. https://doi.org/10.1007/s12471-010-0841-y

Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M., de Ferranti, S., Després, J.P., Fullerton, H.J., Howard, V.J., Huffman, M.D., Judd, S.E., Kissela, B.M., Lackland, D.T., Lichtman, J.H., Lisabeth, L.D., Liu, S., Mackey, R.H., Matchar, D.B., McGuire, D.K., MohlerIII, E.R., Moy, S.C., Muntner, P., Mussolino, M.E., Nasir, K., Neumar, R.W., Nichol, G., Palaniappan, L., Pandey, D.K., Reeves, M.J., Rodriguez, C.J., Sorlie, P.D., Stein, J., Towfighi, A., Turan, T.N., Virani, S.S., Willey, J.Z., Woo, D., Yeh, R.W., Turner, M.B. American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2015). Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation, 131(4), e29–e322. https://doi.org/10.1161/CIR.0000000000000152

Ni, Z., Liu, C., Wu, B., Yang, Q., Douglas, C., & Shaw, R. J. (2018). An mHealth intervention to improve medication adherence among patients with coronary heart disease in China: Development of an intervention. International journal of nursing sciences, 5(4), 322–330. https://doi.org/10.1016/j.ijnss.2018.09.003

Nobre, M., & Domingues, R. (2017). Patient adherence to ischemic heart disease treatment. Revista da Associacao Medica Brasileira (1992), 63(3), 252–260. https://doi.org/10.1590/1806-9282.63.03.252

Park, L.G., Collins, E.G., Shim, J.K., & Whooley, M.A. (2017). Comparing Mobile Health Strategies to Improve Medication Adherence for Veterans with Coronary Heart Disease (Mobile4Meds): Protocol for a Mixed-Methods Study. Journal of Medical Internet Research, 6(7), e134. https://doi.org/10.2196/resprot.7327

Perera, T., Ranasinghe, P., Perera, U., Perera, S., Adikari, M., Jayasinghe, S., & Constantine, G.R. (2012). Knowledge of prescribed medication information among patients with limited English proficiency in Sri Lanka. BMC research notes, 5, 658. https://doi.org/10.1186/1756-0500-5-658

EUGenMed Cardiovascular Clinical Study Group, Regitz-Zagrosek, V., Oertelt-Prigione, S., Prescott, E., Franconi, F., Gerdts, E., Foryst-Ludwig, A., Maas, A.H., Kautzky-Willer, A., Knappe-Wegner, D., Kintscher, U., Ladwig, K.H., Schenck-Gustafsson, K., & Stangl, V. (2016). Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. European heart journal, 37(1), 24–34. https://doi.org/10.1093/eurheartj/ehv598

Rehman, H., Kamal, A.K., Morris, P.B., Sayani, S., Merchant, A.T., & Virani, S.S. (2017). Mobile Health (mHealth) Technology for the Management of Hypertension and Hyperlipidemia: Slow Start but Loads of Potential. Current atherosclerosis reports, 19(3), 12. https://doi.org/10.1007/s11883-017-0649-y

Roffi, M., Patrono, C., Collet, J.P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J.J., Borger, M.A., Brotons, C., Chew, D.P., Gencer, B., Hasenfuss, G., Kjeldsen, K., Lancellotti, P., Landmesser, U., Mehilli, J., Mukherjee, D., Storey, R. F., Windecker, S., & ESC Scientific Document Group (2016). 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). European heart journal, 37(3), 267–315. https://doi.org/10.1093/eurheartj/ehv320

Santo, K., Chow, C.K., Thiagalingam, A., Rogers, K., Chalmers, J., & Redfern, J. (2017). Medication reminder APPs to improve medication adherence in Coronary Heart Disease (MedApp-CHD) Study: a randomised controlled trial protocol. BMJ open, 7(10), e017540. https://doi.org/10.1136/bmjopen-2017-017540

Wiklund, P., Toss, F., Weinehall, L., Hallmans, G., Franks, P. W., Nordström, A., & Nordström, P. (2008). Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men and women. The Journal of clinical endocrinology and metabolism, 93(11), 4360–4366. https://doi.org/10.1210/jc.2008-0804

Zullig, L.L., Ramos, K., & Bosworth, H.B. (2017). Improving Medication Adherence in Coronary Heart Disease. Current cardiology reports, 19(11), 113. https://doi.org/10.1007/s11886-017-0918-y




How to Cite

Putra, R. P. ., Rochmawati, I. D. ., & Prima, D. A. . (2022). IAI SPECIAL EDITION: The impact of mobile application: "Friends of Heart" in knowledge and compliance of patients with coronary heart disease . Pharmacy Education, 22(2), p. 36–40. https://doi.org/10.46542/pe.2022.222.3640



Special Edition