IAI SPECIAL EDITION: Influence of dispersing solvent on curcumin dissolution from solid dispersions prepared using hydroxypropyl methylcellulose-polyvinylpyrrolidone K30
DOI:
https://doi.org/10.46542/pe.2022.222.7478Keywords:
Curcuma longa , Dissolution , Polyvinylpyrrolidone K30, Solid dispersions, SolventAbstract
Background: Preparation of lipophilic compounds into solid dispersion formulations (SDs) has been credited with increasing their dissolution rate. Understanding the role of the dispersing solvent is crucial to the SDs preparation. Drug/carrier-solvent immiscibility may decrease the dissolution rate.
Aim: This work aimed to study the effect of different dispersing solvents on a curcumin dissolution.
Method: A solvent evaporation method was used in the SD preparation. The formulation was prepared at 30% w/w drug load contained Curcuma longa and a carrier mixture of Hydroxy Propyl Methylcellulose (HPMC)/ Polyvinylpyrrolidone K30 (PVP K30). As for the dispersing solvent, the study used ethanol, ethyl acetate, and ethanol/ethyl acetate solvent mixture. The dissolution profile was obtained and analysed for the dissolution-efficiency (DE).
Result: The DE values of 38.5%, 37.8%, and 32.0% were obtained using ethanol, ethyl acetate, and ethanol-ethyl acetate mixture.
Conclusion: The results show that there is a significant impact of using different SD solvents on curcumin dissolution.
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