IAI SPECIAL EDITION: White Turmeric (Kaempferia rotunda L.) extract liquid soap preparation for feminine hygiene and effectiveness against Candida albicans

Authors

  • Sofi Nurmay Stiani STIKes Salsabila Serang, Banten, Indonesia https://orcid.org/0000-0002-9703-8835
  • Lila Ardiani Putri Universitas Mathla'ul Anwar Banten, Banten, Indonesia
  • Yusransyah STIKes Salsabila Serang, Banten, Indonesia https://orcid.org/0000-0002-2548-5847
  • Dimas Danang Indriatmoko Universitas Mathla'ul Anwar Banten, Banten, Indonesia

DOI:

https://doi.org/10.46542/pe.2022.222.7984

Keywords:

Candida albicans, Kaempferia rotunda L., Leucorrhoea, Liquid soap, White turmeric extract

Abstract

Background: Kaempferia rotunda L. (white turmeric) contains alkaloids, phenols, saponins, glycosides, steroids, terpenoids, and other ingredients with antimicrobial, anticancer, antiallergic, antioxidant, analgesic, and antifungal properties. Meanwhile, vaginal discharge or fluor albus is an excessive release of non-bloody fluid caused by the Candida albicans fungus.   

Objective: This study aimed to formulate white turmeric extracts (Kaempferia rotunda L.) into standard liquid soap for feminine hygiene and to determine the level of antifungal activity against Candida albicans.   

Methods: The liquid soap was produced by the maceration of white turmeric in 70% ethanol, which was evaporated until a thick extract was formed. This soap preparation included 7% stearic acid, 1% adeps lanae, 2% triethanolamine (TEA), 5% glycerol, white turmeric extract (at concentrations of 20%, 25%, and 30%), vanilla oil, and distilled water added up to 100 mL. Furthermore, the well method was used to test the antifungal activity of the preparations, and analysis was done on SPSS.   

Results: The results showed that the white turmeric ethanol extract was effective against the Candida albicans fungus at concentrations of 25% and 30%, with inhibitory diameters of 11 mm and 15 mm (categorised as powerful), respectively. Also, the liquid soap preparations of the extract revealed antifungal activity at a concentration of 30%, with a 9.6 mm inhibition diameter (medium category). The soap met Indonesian National Standard (SNI) requirements, including organoleptic, pH, high foam, and viscosity properties.    

Conclusion: The white turmeric ethanol extract can be formulated into a feminine hygiene soap with antifungal activity at a concentration of 30%.

Author Biographies

Sofi Nurmay Stiani, STIKes Salsabila Serang, Banten, Indonesia

Department of Pharmacy

Lila Ardiani Putri, Universitas Mathla'ul Anwar Banten, Banten, Indonesia

Faculty of Science Pharmacy and Health

Yusransyah, STIKes Salsabila Serang, Banten, Indonesia

Department of Pharmacy

Dimas Danang Indriatmoko, Universitas Mathla'ul Anwar Banten, Banten, Indonesia

Faculty of Science Pharmacy and Health

References

Anna K Jager, S.H.F. (2014). Correlation between Plant Secondary Metabolites and Their Antifungal Mechanisms–A Review. Medicinal & Aromatic Plants. https://doi.org/10.4172/2167-0412.1000154

Ariami, P., Danuyanti, I., & Anggraeni, B.R. (2017). The Effectiveness of Mangosteen Peel Tea (Garcinia mangostana L) as Antimicrobial against the Growth of Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteria. Laboratory Technology

Astutiningsih, C., Octaviani, R., & Suratiningsih, S. (2014). Inhibitory power of essential oil and waste extract from distillation of white turmeric rhizome (Kaempferia rotunda L.) on growth Candida albicans ATCC 10231. Jurnal Farmasi Sains Dan Komunitas, 11(1), 18-22

Bhaskara, G. Y. (2012). Uji Daya Antifungal Ethanol Extract of Bay Leaf (Syzygium polianthum [Wight] Walp.) against Candida albicans Atcc 10231 secara in Vitro. Medical Faculty of Universitas Muhammadiyah Surakarta

Kumar, A., Kumar, S., & Navneet. (2015). Antimicrobial activity and phytochemical analysis of Kaempferia rotunda L. rhizomes. Der Pharmacia Lettre, 7(9), 389-395

Lachman, L., Liebarman, H.A., dan Kanig J.L. (1986). Theory and Practice of Industrial Pharmacy II, translated by Siti Suyatmi, Edition III (III). Jakarta: University of Indonesia

Lolok, N., Awaliyah, N., & Astuti, W. (2020). Formulation and Activity Test of Liquid Soap Preparations for Feminine Cleansing Extracts of Waru (Hibiscus tiliaceus) Leaves Against Fungus Candida albicans. Jurnal Mandala Pharmacon Indonesia. https://doi.org/10.35311/jmpi.v6i01.53

Madduluri, S., Babu Rao, K., & Sitaram, B. (2013). In vitro evaluation of antibacterial activity of five indigenous plants extract against five bacterial pathogens of human. International Journal of Pharmacy and Pharmaceutical Sciences

Maysaroh, S., & Mariza, A. (2021). Knowledge About White in Young Women. Jurnal Kebidanan Malahayati, 7(1), 104-108. https://doi.org/10.33024/jkm.v7i1.3582

Ningsih, D.R. (2017). Leaf extract of mango (Mangifera indica L.) As antifume against candida albicans and identification of compound class. Jurnal Kimia Riset. https://doi.org/10.20473/jkr.v2i1.3690

Oliveira, V.M., Carraro, E., Auler, M. E., & Khalil, N.M. (2016). Quercetin and rutin as potential agents antifungal against Cryptococcus spp. Brazilian Journal of Biology. https://doi.org/10.1590/1519-6984.07415

Rahman, F.A., Haniastuti, T., & Utami, T.W. (2017). Skrining fitokimia dan aktivitas antibakteri ekstrak etanol daun sirsak (Annona muricata L.) pada Streptococcus mutans ATCC 35668. Majalah Kedokteran Gigi Indonesia. https://doi.org/10.22146/majkedgiind.11325

Rahmi, I.W., Nurhikma, E., Badia, E., & Ifaya, M. (2017). Formulasi Sabun Pembersih Kewanitaan (Feminime Hygiene) dari Ekstrak Kulit Buah Durian (Durio zibethinus Murray). Jurnal Mandala Pharmacon Indonesia. https://doi.org/10.35311/jmpi.v3i02.8

Raymond C Rowe, P.J.S. and M.E.Q. (2009). Handbook of Pharmaceutical Excipients (6th ed.). London: American Pharmaceutical Association., 6

Sumathi, S., Iswariya, G. T., Sivaprabha, B., Dharani, B., Radha, P., & Padma, P.R. (2013). Comparative Study of Radical Scavenging Activity and Phytochemical Analysis of Fresh and Dry Rhizomes of Curcuma zedoaria. International Journal of Pharmaceutical Science and Research

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Published

2022-03-31

How to Cite

Stiani, S. N. ., Putri, L. A. ., Yusransyah, & Indriatmoko, D. D. . (2022). IAI SPECIAL EDITION: White Turmeric (Kaempferia rotunda L.) extract liquid soap preparation for feminine hygiene and effectiveness against Candida albicans. Pharmacy Education, 22(2), p. 74–84. https://doi.org/10.46542/pe.2022.222.7984

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Special Edition