IAI SPECIAL EDITION: Development of novel curcumin nanoemulgel: Optimisation, characterisation, and ex vivo permeation

Authors

  • Ferdy Firmansyah Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia
  • Wildan Khairi Muhtadi Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia https://orcid.org/0000-0001-6635-2090
  • Sepfira Indriani Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia
  • Maulana Dziya Ulhaq Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia
  • Suci Rizki Auliya Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia
  • Benni Iskandar Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia
  • Nesa Agistia Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Tampan, Pekanbaru, Riau, Indonesia
  • Lutfi Chabib Islamic University of Indonesia, Yogyakarta, Indonesia https://orcid.org/0000-0002-1250-1406

DOI:

https://doi.org/10.46542/pe.2022.222.98103

Keywords:

Curcumin, Nanoemulsions, Nanoemulgels, Permeation

Abstract

Introduction: Curcumin (Crc) is widely used as an antioxidant and an anti-inflammatory agent. Its low solubility limits its oral bioavailability, thus the need to develop a transdermal nanoformulation of Crc.   

Aim: This study aimed to obtain the stable formula of Crc-loaded nanoemulgels (Crc-NEGs) possessing good characteristics.   

Methods: The nanoemulsion (NE) was prepared by titration of the water phase into the mixture of oil, surfactant, and cosurfactant. Crc-NEs optimum formula was obtained by the simplex lattice design (SLD) method. Crc-NEGs were prepared using Carbopol 940 as the gelling agent, and subsequently, its freeze-thaw stability was observed. The ex vivo permeation study of Crc-NEGs was conducted using Franz diffusion cell.   

Results: The optimum formula of Crc-NEs showed good characteristics in terms of transmittance, particle size, polydispersity index, and zeta potential. Crc-NEGs were found stable through freeze-thaw stability. The ex vivo permeation study illustrated the higher amount of Crc penetrated from NEGs compared to the control (p <0,05).   

Conclusion: The Crc-NEGs formula has the potential to be the novel effective delivery method of curcumin.

Author Biography

Lutfi Chabib, Islamic University of Indonesia, Yogyakarta, Indonesia

Department of Pharmacy

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Published

31-03-2022

How to Cite

Firmansyah, F. ., Muhtadi, W. K. ., Indriani, S. ., Ulhaq, M. D. ., Auliya, S. R. ., Iskandar, B. ., Agistia, N. ., & Chabib, L. . (2022). IAI SPECIAL EDITION: Development of novel curcumin nanoemulgel: Optimisation, characterisation, and ex vivo permeation. Pharmacy Education, 22(2), p. 98–103. https://doi.org/10.46542/pe.2022.222.98103

Issue

Vol. 22 No. 2 (2022): IAI Special Edition

Section

Special Edition

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