IAI SPECIAL EDITION: Phytochemical screening and antidiabetic activities test of ethanol extract from Syzygium cumini L. seeds in male Wistar rats induced by alloxan

Authors

  • Lia Puspitasari ITEKES Bali, Denpasar, Bali, Indonesia
  • Made Asmarani Dira ITEKES Bali, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.46542/pe.2022.222.165168

Keywords:

Antidiabetic, Jamblang fruit seeds, Phytochemical screening, Syzygium cumini

Abstract

Introduction: The ethanol extract of the jamblang fruit seed (Syzygium cumini L.) is known to have an antidiabetic effect and this is further confirmed by the high intensity of its α-amylase inhibitory effect.   

Aim: The purpose of this study was to determine the antidiabetic activity of jamblang fruit seed extract in reducing blood sugar levels.    

Method: Phytochemical screening was carried out on the ethanol extract from jamblang fruit seeds. Twenty-eight male wistar rats were given alloxan to induce diabetes. The rats were divided into four groups: normal control, negative control (CMC-Na), positive control (Glibenclamide), and a group that was given ethanol extract of jamblang seeds. Measurement of blood glucose levels was carried out on day 0 and day 15.   

Results: The phytochemical screening results show that the ethanolic extract of jamblang fruit seeds (Syzygium cumini L.) contains alkaloids, flavonoids, saponins, tannins, and polyphenols, as well as steroids and triterpenoids. The group being treated with ethanol extract from jamblang seeds showed decreased blood sugar levels on day 15, indicating the antidiabetic effectiveness of the extract.  

Conclusion: Ethanol extract from jamblang seeds (Syzygium cumini) contains alkaloids, flavonoids, saponins, tannins, polyphenols, steroids, and triterpenoids; and is able to reduce blood glucose levels of male wistar rats induced with alloxan.

Author Biographies

Lia Puspitasari, ITEKES Bali, Denpasar, Bali, Indonesia

Community and Clinical Pharmacy Study Program

Made Asmarani Dira, ITEKES Bali, Denpasar, Bali, Indonesia

Community and Clinical Pharmacy Study Program

References

Bhat, M., Zinjarde,S.S., Bhargava, S.Y., Kumar, A.R., Joshi, B.N. (2011). Antidiabetic Indian Plants: A Good Source of Potent Amylase Inhibitors. Evidence-Based Complementary and Alternative Medicine, 2011, 810207, 1-6. https://doi.org/10.1093/ecam/nen040

Gajera, H.P., Gevariya, S.N., Hirpara, D.G., Patel, S.V. (2017). Antidiabetic and Antioxidant Functionality Associated with Phenolic Constituents from Fruit Parts of Indigenous Black Jamun (Syzygium cumini L) Landraces. J Food Sci Technol, 54(10), 3180-3191. https://doi:10.107/s13197-017-2756-8

Perera, P.R.D., Ekanayake, S., Ranaweera, K.K.D.S. (2017). Antidiabetic Compounds in Syzygium cumini Decoction and Ready to Serve Herbal Drink. Evidence-Base Complementary and Alternative Medicine, 2017, 1083589, 1-5. https://doi.org/10.1155/2017/1083589

Prabakaran, K & Shanmugave, G. (2017). Antidiabetic Activity and Phytochemical Constituents of Syzygium cumini Seeds in Puducherry Region, South India. International Journal of Pharmacognosy and Phytochemical Research, 9(7), 985-989. https://doi.org/10.25258/phyto.v9i07.11168

Proma, N.M., Naima, J., Islan., M.R., Papel., J.A., Rahman, M.M., Hossain, M.K. (2017). Phytochemical Constituents and Antidiabetic Properties of Syzygium Cumini LinN. Seed. IJPSR. 9(5), 1806-1814

Tiwari, P., Kumar, B., Kaur, M., Kaur, G., Kaur, H. (2011). Phytochemical screening and Extraction: A Review. Ipharmsciencia,1(1), 98-106

Downloads

Published

2022-03-31

How to Cite

Puspitasari, L. ., & Dira, M. A. . (2022). IAI SPECIAL EDITION: Phytochemical screening and antidiabetic activities test of ethanol extract from Syzygium cumini L. seeds in male Wistar rats induced by alloxan. Pharmacy Education, 22(2), p. 165–168. https://doi.org/10.46542/pe.2022.222.165168

Issue

Section

Special Edition