IAI SPECIAL EDITION: Stevia rebaudiana as a nutraceutical for COVID-19 patients with no sugar diet during recovery and its nanoparticle application


  • Lutfi Chabib Universitas Islam Indonesia, Yogyakarta, Indonesia
  • Arman Suryani Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Sherina Nabila Putri Hakim Universitas Islam Indonesia, Yogyakarta, Indonesia
  • Muhammad Ikhwan Rizki Universitas Lambung Mangkurat, South Kalimantan, Indonesia
  • Ferdy Firmansyah Sekolah Tinggi Ilmu Farmasi Riau, Riau, Indonesia
  • Yulianto Universitas Islam Indonesia, Yogyakarta, Indonesia
  • Fitra Romadhonsyah Universitas Islam Indonesia, Yogyakarta, Indonesia




COVID-19, Diabetes mellitus, Nanoparticle, Nutraceutical, Stevia rebaudiana


Introduction: Some patients with comorbidity such as diabetes are at risk of worsening after being infected with the COVID-19 and they usually adjust their diet during the recovery process.   

Aim: To explore the use of Stevia rebaudiana leaves as a natural sweetener recommended for COVID-19 patients and the nanoparticle approach  of S. rebaudiana extract to improve the efficacy.   

Methods: Four electronic databases (Google Scholar, PubMed, Scopus, and ScienceDirect) were used  with specified inclusion and exclusion criteria set.   

Results: The glycosides produced by S. rebaudiana are 300 times sweeter than sucrose, low in calories, and can control blood sugar levels and increase insulin secretion. The application of nanoparticles in S. rebaudiana extract is a new step to maximise efficacy, increase stability and solubility.   

Conclusion: S. rebaudiana can be used as an alternative diet for COVID-19 diabetes patients. The application of the nanoparticles can increase the stability and solubility, thus improving the efficacy.

Author Biographies

Lutfi Chabib, Universitas Islam Indonesia, Yogyakarta, Indonesia

Faculty of Mathematics and Science

Arman Suryani, Universitas Gadjah Mada, Yogyakarta, Indonesia

Faculty of Pharmacy

Sherina Nabila Putri Hakim, Universitas Islam Indonesia, Yogyakarta, Indonesia

Faculty of Mathematics and Science

Muhammad Ikhwan Rizki, Universitas Lambung Mangkurat, South Kalimantan, Indonesia

Pharmacy Study Program, Faculty of Mathematics and Science

Yulianto, Universitas Islam Indonesia, Yogyakarta, Indonesia

Faculty of Mathematics and Science

Fitra Romadhonsyah, Universitas Islam Indonesia, Yogyakarta, Indonesia

Faculty of Mathematics and Science


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How to Cite

Chabib, L. ., Suryani, A. ., Hakim, S. N. P. ., Rizki, M. I., Firmansyah, F. ., Yulianto, & Romadhonsyah, F. . (2022). IAI SPECIAL EDITION: Stevia rebaudiana as a nutraceutical for COVID-19 patients with no sugar diet during recovery and its nanoparticle application. Pharmacy Education, 22(2), p. 174–179. https://doi.org/10.46542/pe.2022.222.174179



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