IAI SPECIAL EDITION: Stevia rebaudiana as a nutraceutical for COVID-19 patients with no sugar diet during recovery and its nanoparticle application
DOI:
https://doi.org/10.46542/pe.2022.222.174179Keywords:
COVID-19, Diabetes mellitus, Nanoparticle, Nutraceutical, Stevia rebaudianaAbstract
Introduction: Some patients with comorbidity such as diabetes are at risk of worsening after being infected with the COVID-19 and they usually adjust their diet during the recovery process.
Aim: To explore the use of Stevia rebaudiana leaves as a natural sweetener recommended for COVID-19 patients and the nanoparticle approach of S. rebaudiana extract to improve the efficacy.
Methods: Four electronic databases (Google Scholar, PubMed, Scopus, and ScienceDirect) were used with specified inclusion and exclusion criteria set.
Results: The glycosides produced by S. rebaudiana are 300 times sweeter than sucrose, low in calories, and can control blood sugar levels and increase insulin secretion. The application of nanoparticles in S. rebaudiana extract is a new step to maximise efficacy, increase stability and solubility.
Conclusion: S. rebaudiana can be used as an alternative diet for COVID-19 diabetes patients. The application of the nanoparticles can increase the stability and solubility, thus improving the efficacy.
References
Aghajanyan, A., Movsisyan, Z., & Trchounian, A. (2017). Antihyperglycemic and Antihyperlipidemic Activity of Hydroponic Stevia rebaudiana Aqueous Extract in Hyperglycemia Induced by Immobilization Stress in Rabbits. BioMed Research International, 1-6. https://doi.org/10.1155/2017/9251358
Ahmad, U., Ahmad, R.S., Arshad, M.S., Mushtaq, Z., Hussain, S.M., & Hameed, A. (2018). Antihyperlipidemic efficacy of aqueous extract of Stevia rebaudiana Bertoni in albino rats. Lipids in Health and Disease, 17(1), 175. https://doi.org/10.1186/s12944-018-0810-9
Alahmad, K. (2018). Stevia Rebaudiana Bertoni: Description and Chemical Composition. International Journal of Agriculture Innovations and Research, 7(2), 230-232
Ashwell, M. (2015). Stevia, Nature's Zero-Calorie Sustainable Sweetener: A New Player in the Fight Against Obesity. Nutrition Today, 50(3), 129-134. https://doi.org/10.1097/nt.0000000000000094
Atteh, J., Onagbesan, O., Tona, K., Buyse, J., Decuypere, E., & Geuns, J. (2011). Potential use of Stevia rebaudiana in animal feeds. Archivos de Zootecnia, 60(229), 133-136. https://doi.org/10.4321/S0004-05922011000100015
Barwal, I., Sood, A., Sharma, M., Singh, B., & Yadav, S.C. (2013). Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as an antidiabetic nanomedicine. Colloids and Surfaces B: Biointerfaces, 101(2013), 510-516. http://dx.doi.org/10.1016/j.colsurfb.2012.07.005
Boonkaewwan, C., & Burodom, A. (2013). Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells: Anti-inflammatory and immunomodulatory activities of stevia compounds. Journal of the Science of Food and Agriculture, 93(15), 3820–3825. https://doi.org/10.1002/jsfa.6287
Bujaka, T., Nizioł-Łukaszewskaa, Z., Gaweł-Bębenb, K., Sewerync, A., Kucharekd, M., Rybczyńska-Tkaczykb, K., & Matysiake, M. (2015). The application of different Stevia rebaudiana leaf extracts in the “green synthesis” of AgNPs. Green Chemistry Letters and Reviews, 8(3–4), 78–87. https://doi.org/10.1080/17518253.2015.1111431
Chauhan, B., Kumar, G., Kalam, N., & Ansari, S.H. (2013). Current concepts and prospects of herbal nutraceutical: A review. Journal of Advanced Pharmaceutical Technology & Research. 4(1), 4-8. https://doi.org/10.4103/2231-4040.107494
Chughtai, M.F.J., Pasha, I., Zahoor, T., Khaliq, A., Ahsan, S., Wu, Z., Nadeem, M., Mehmood, T., Amir, R.M., Yasmin, I., Liaqat, A., & Tanweer, S. (2020). Nutritional and therapeutic perspectives of Stevia rebaudiana as emerging sweetener; a way forward for sweetener industry. CyTa - Journal of Food, 18(1), 164-177. https://doi.org/10.1080/19476337.2020.1721562
Gasmalla, M.A.A., Yang, R., Amadou, I., & Hua, X. (2014). Nutritional composition of Stevia rebaudiana Bertoni leaf: Effect of drying method. Tropical Journal of Pharmaceutical Research, 13(1), 61–65. http://dx.doi.org/10.4314/tjpr.v13i1.9
Gupta, E., Purwa, S., Sundaram, S., & Rai, G.K. (2013). Nutritional and therapeutic values of Stevia rebaudiana: A review. Journal of Medicinal Plants Research, 7(46), 3343-3353. https://doi.org/10.5897/JMPR2013.5276
Hossain, M.F., Islam, M.T., Islam, M.A., & Akhtar, S. (2017). Cultivation And Uses Of Stevia (Stevia rebaudiana Bertoni): A Review. African Journal of Food, Agriculture, Nutrition and Development, 17(4), 12745-12757. https://doi.org/10.18697/AJFAND.80.16595
Karyono, D.R., & Wicaksana, A.L. (2020). Current prevalence, characteristics, and comorbidities of patients with COVID-19 in Indonesia. Journal of Community Empowerment for Health, 3(2), 77-84. https://doi.org/10.22146/jcoemph.57325
Kim, I., Yang, M., Lee, O., & Nam-Suk, K. (2011). The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts. LWT–Food Science and Technology, 44(5), 1328-1332. http://dx.doi.org/10.1016/j.lwt.2010.12.003
Kristanto, Y., & Hartono, A.R. (2021). Anti-diabetic properties of Stevia rebaudiana Bertoni as sugar substitute: a mini-review. Bali Medical Journal, 10(1), 189-193. http://dx.doi.org/10.15562/bmj.v10i1.2259
Latarissa, I.R., Barliana, M.I., & Lestari, K. (2020). A Comprehensive Review of Stevia rebaudiana Bertoni effects on Human Health and Its Mechanism. Journal of Advanced Pharmacy Education & Research10(2), 91-95
Lemus-Mondaca, R., Vega-Gálvez, A., Rojas, P., Stucken, K., Delporte, C., Valenzuela-Barra, G., Jagus, R.J., Agüero, M.V., & Pasten, A. (2018). Antioxidant, antimicrobial and anti-inflammatory potential of Stevia rebaudiana leaves: effect of different drying method. Journal of Applied Research on Medicinal and Aromatic Plants, 11, 37–46. https://doi.org/10.1016/j.jarmap.2018.10.003
Li, G., Wang, R., Quampah, A.J., Rong, Z., Shi, C., & Wu, J. (2011). Calibration and prediction of amino acids in stevia leaf powder using near infrared refl ectance spectroscopy. Journal of Agricultural and Food Chemistry, 59(24), 13065-13071. https://doi.org/10.1021/jf2035912
Limanto, A. (2017). Stevia, Pemanis Pengganti Gula dari Tanaman Stevia rebaudiana. Jurnal Kedokteran Meditek, 23 (61), 1-12. https://doi.org/10.36452/jkdoktmeditek.v23i61.1466
Majlesi, Z., Ramezani, M., & Gerami, M. (2018). Investigation on some main glycosides content of Stevia rebaudian B. under different concentrations of commercial and synthesized silver nanoparticles. Pharmaceutical and Biomedical Research, 4(1), 8-14. https://doi.org/10.18502/pbr.v4i1.140
Martien, R., Adhyatmika, A., Irianto, I.D., Farida, V., & Sari, D.P. (2012). Perkembangan teknologi nanopartikel sebagai sistem penghantaran obat. Indonesian Journal of Pharmacy, 8(1), 133–144. https://doi.org/10.22146/farmaseutik.v8i1.24067
Mutmainah, Kusmita, L., Martono, Y., Franyoto, Y.D., Wulandari, R.P., & Kusumaningrum, T.D. (2019). Antioxidant activity, phenol and flavonoid content, and formulation cream of Stevia rebaudiana Bert. Journal of Physics: Conf. Series, 1217, 012152. http://dx.doi.org/10.1088/1742-6596/1217/1/012152
Nugraha, R.V., Ridwansyah, H., Ghozali, M., Khairani, A.F., & Atik, N. (2020). Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons. Evidence-Based Complementary and Alternative Medicine, 1–12. https://doi.org/10.1155/2020/2560645
Nwosu, O.K. & Ubaoji, K.I. (2020). Nutraceuticals: History, Classification and Market Demand. Functional Foods and Nutraceuticals. Springer, Cham. 3-22. https://doi.org/10.1007/978-3-030-42319-3_2
Permatasari, D.R.I., Purwadi., & Evanuarini, H. (2018). The Quality of Kefir using Stevia (Stevia rebaudiana Bertoni) Leaf Flour Addition as Natural Sweetener. Jurnal Ilmu dan Teknologi Hasil Ternak, 13(2), 91-97. http://doi.org/10.21776/ub.jitek.2018.013.02.3
Philippaert, K., Pironet, A., Mesuere, M., Sones, W., Vermeiren, L., Kerselaers, S., Pinto, S., Segal, A., Antoine, N., Gysemans, C., Laureys. J., Lemaire, K., Gilon, P., Cuypers, E., Tytgat, J., Mathieu, C., Schuit, F., Rorsman, P., Talavera, K., Voets, T., & Vennekens, R. (2017). Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. Nature Communications, 8(14733), 1-16. http://doi.org/ 10.1038/ncomms14733
Ray, J., Kumar, S., Laor, D., Shereen, N., Nwamaghinna, F., Thomson, A., Perez, J.P., Soni, L., & McFarlane, S.I. (2020). Effects of Stevia Rebaudiana on Glucose Homeostasis, Blood Pressure and Inflammation: A Critical Review of Past and Current Research Evidence', International Journal of Clinical Research & Trials, 5(142), 1-6. https://doi.org/10.15344/2456-8007/2020/142
Roncon, L., Zuinb, M., Rigatellic, G., & Zuliani, G. (2020). admission and poor short-term outcome. Journal of Clinical Virology, 127(104354), 6. https://dx.doi.org/10.1016%2Fj.jcv.2020.104354
Salehi, B., López, M.D., Martínez-López, S., Victoriano, M., Sharifi-Rad, J., Martorell, M., Rodrigues, C.F., & Martins, N. (2019). Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches. Phytotherapy Research, 33(11), 2904-2917. https://doi.org/10.1002/ptr.6478
Shinde, N., Bangar, B., Deshmukh, S., & Kumbhar, P. (2014). Nutraceuticals: A Review on current status. Research Journal of Pharmacy and Technology. 7(1), 110-113
Srihasam, S., Thyagarajan, K., Korivi, M., Lebaka, V.R., & Mallem, S.P.R. (2020). Phytogenic Generation of NiO Nanoparticles Using Stevia Leaf Extract and Evaluation of Their In-Vitro Antioxidant and Antimicrobial Properties. Biomolecules, 10(89), 2-12. https://doi.org/10.3390/biom10010089
Singh, S., Garg, V., & Yadav, D. (2013). Antihyperglycemic And Antioxidative Ability Of Stevia Rebaudiana (Bertoni) Leaves In Diabetes Induced Mice. International Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 297-302
Wang, Z., Xue, L., Guo, C., Han, B., Pan, C., Zhao, S., Song, H., & Ma, Q. (2012). Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-κB pathway. Biochemical and Biophysical Research Communications, 417(4), 1280–1285. https://doi.org/10.1016/j.bbrc.2011.12.130
WHO (2021) Novel Coronavirus (Online). Available at: https://www.who.int/indonesia/news/novel-coronavirus (Accessed: 25 July 2021)
Widodo, W., Munawaroh, N., & Indratiningsih, I. (2015). Produksi low calorie sweet bio-yoghurt dengan penambahan ekstrak daun stevia (stevia rebaudiana) sebagai pengganti gula. Jurnal Agritech, 35(04), 464-473. https://doi.org/10.22146/agritech.9331
Zlabur, J.S., Voća, S., Dobričević, N., Ježek, D., Bosiljkov, T., & Brnčić, M. (2013). Stevia rebaudiana Bertoni - A Review of Nutritional and Biochemical Properties of Natural Sweetener, Agriculturae Conspectus Scientificus, 78(1), 25-30