The relationship of body mass index and T score in healthy and knee osteoarthritis women

Authors

  • Anisyah Achmad Departement of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia & Doctoral Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Suharjono Departement of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Joewono Soeroso Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Budi Suprapti Departement of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Siswandono Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Liza Pristianty Departement of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Mahardian Rahmadi Departement of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Jusak Nugraha Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia
  • Yoki Surya Department of Orthopedics and Traumatology, Brawijaya Army Hospital, Surabaya, Indonesia
  • Satria Pandu Persada Isma Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Brawijaya and Aisyiyah Islamic Hospital, Malang, Indonesia
  • Erreza Rahadiansyah Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Ilmia Fahmi Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya, Malang, Indonesia
  • Catur Saptaning Wilujeng Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya, Malang, Indonesia

DOI:

https://doi.org/10.46542/pe.2023.234.321324

Keywords:

Bone mass index, Bone mineral density, Menopause, Osteoarthritis, T score

Abstract

Background: Osteoarthritis (OA) is a chronic, degenerative, slowly progressive disease common in women with multiple aetiology. Osteoarthritis occurs simultaneously with the reduction in bone mineral density (BMD)while a high bone mass index (BMI) value is one of the risk factors for OA.

Objective: The purpose of this study was to determine the effect of BMI and BMD in healthy and knee OA women.

Method: The study was conducted in an orthopaedic outpatient clinic in 2021. This is a quantitative descriptive study with accidental cross-sectional samplings. The Mann-Whitney test was used to analyse the data.

Result: Subjects included in the inclusion criteria obtained 74 OA and 49 control groups. The largest subjects in the OA group were aged 56-65 years old  (32, 43.24%), obese (51, 68.92%), and post-menopause (49, 66.22%). At the same time, the T score category was normal (14, 18.91%), osteopenia (22, 29.73%), and osteoporosis (38, 51.35%). Statistical analysis found a significant relationship between BMI and BMD (p = 0.002, p = 0.001) in controls and OA groups.

Conclusion: Disorders of BMI and BMD are indicators of risk for OA. High BMI and low BMD values occur in women with knee OA. There is a relationship between BMI and BMD in healthy and knee OA women.

References

Bennell, K.L., Nelligan, R.K., Kimp, A.J., Wrigley, T.V., Metcalf, B., & Kasza, J. (2019). Comparison of weight bearing functional exercise and non-weight bearing quadriceps strengthening exercise on pain and function for people with knee osteoarthritis and obesity: Protocol for the TARGET randomised controlled trial. BMC Musculoskeletal Disorders, 20(1), 291. https://doi.org/10.1186/s12891-019-2662-5

Center for Disease Control and Prevention (CDC). (2021). Osteoarthritis. Accessed from http://www.cdc.gov/arthritis/basics/osteoarthritis.html

Kambayana, G. (2017). Managemen Rasional Osteoatritis dan Osteoporosis Divisi Reumatologi-imunologi Bag/SMF Ilmu Penyakit Dalam, FK UNUD/RSUP Sanglah Denpasar Bali. National Rheumatology Osteoporosis and Herbal Medicine.

Mochizuki, T., Koga, Y., Tanifuji, O., Sato, T., Watanabe, S., Koga, H., Kobayashi, K., Omori, G., & Endo, N. (2019). Effect on inclined medial proximal tibial articulation for varus alignment in advanced knee osteoarthritis. Journal Exp Orthop, 6(1), 14. https://doi.org/10.1186/s40634-019-0180-x

Nevitt, M.C,. Zhang, Y., Javaid, M.K., Neogi, T., Curtis, J.R., & Niu, J. (2010). High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: The MOST study. Ann Rheum Dis, 69,163-168. https://doi.org/10.1136/ard.2008.099531

Park, E.H., Kim, J.S., Lee, J.S., Lee, Y.J., Song, Y.W., & Lee, E.Y. (2018). Compound K inhibits interleukin-1β -induced expression of inflammatory mediators and matrix metalloproteinases by inhibiting mitogen-activated protein kinase activation in chondrocytes. Journal Rheum Dis, 25, 188-196.

Razek, A.A., & El-Basyouni, S.R. (2016). Ultrasound of knee osteoarthritis: Interobserver agreement and correlation with Western Ontario and McMaster Universities Osteoarthritis. Clin Rheumatol, 35(4), 997–1001. https://doi.org/10.1007/s10067-015-2990-2

Shun, P.W., Po, K.W., Cheng, H.L., Cheng, M.S., Yung, C.C., & Cheng, E.H. (2021). Association of osteoporosis and varus inclination of the tibial plateau in postmenopausal women with advanced osteoarthritis of the knee. BMC Musculoskeletal Disorders, 22, 22. https://doi.org/10.1186/s12891-021-04090-2

Silverwood, V., Blagojevic-Bucknall, M., Jinks, C., Jordan, J.L., Protheroe, J., & Jordan, K.P. (2015). Current evidence on risk factors for knee osteoarthritis in older adults: A systematic review and meta-analysis. Osteoarthritis Cartilage, 23, 507-515. https://doi.org/10.1016/j.joca.2014.11.019

Song, G.G., & Lee, Y.H. (2019). Causal association between bone mineral density and osteoarthritis: A mendelian Randomisation Study. Journal of Rheumatic Diseases, 26, 2. https://doi.org/10.4078/jrd.2019.26.2.104

Tang, J., Liu, T., Wen, X., Zhou, Z., Yan, J., & Gao, J. (2021). Estrogen-related receptors: Novel potential regulators of osteoarthritis pathogenesis. Molecular Medicine, 27(1), 5.https://doi.org/10.1186/s10020-021-00270-x

Xu, X., Li, X., Liang, Y., Ou, Y., Huang, J., & Xiong, J. (2019). Estrogen modulates cartilage and subchondral bone remodeling in an ovariectomised rat model of postmenopausal osteoarthritis. Medical science monitor: International Medical Journal of Experimental and clinical research, 25, 3146-3153. https://doi.org/10.12659/msm.916254

Downloads

Published

10-10-2023

How to Cite

Achmad, A., Suharjono, Soeroso, J., Suprapti, B., Siswandono, Pristianty, L., Rahmadi, M., Nugraha, J., Surya, Y., Isma, S. P. P., Rahadiansyah, E., Fahmi, I., & Wilujeng, C. S. (2023). The relationship of body mass index and T score in healthy and knee osteoarthritis women. Pharmacy Education, 23(4), p. 321–324. https://doi.org/10.46542/pe.2023.234.321324

Issue

Section

Special Edition