Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride

Authors

  • Lusia Oktora Ruma Kumala Sari University of Jember, Jember, Indonesia
  • Lintang Qonita Fardliana University of Jember, Jember, Indonesia
  • Dwi Nurahmanto University of Jember, Jember, Indonesia
  • Eka Deddy Irawan University of Jember, Jember, Indonesia

DOI:

https://doi.org/10.46542/pe.2023.234.2731

Keywords:

Carbomer, Ciprofloxacin hydrochloride, Ethyl cellulose, Microsphere, Mucoadhesive

Abstract

Background: Ciprofloxacin hydrochloride (CH) is an antibiotic used to treat urinary tract infections. CH has a short half-life and low bioavailability. Microspheres combined with a mucoadhesive system can increase the residence time of the drug in the stomach to increase the bioavailability of CH.     

Objective: This research was conducted to obtain the best amount of carbomer as a polymer mucoadhesive and ethyl cellulose as a matrix polymer based on factorial design.     

Method: The factorial design 22 was used to determine the amount of carbomer and ethyl cellulose to produce optimum mucoadhesive microspheres. Three responses were observed in this study: particle size, entrapment efficiency, and mucoadhesive strength.     

Result: The resulting entrapment efficiency was 69.0%, particle size was 404.52 nm, and mucoadhesive strength was 64.3 grams, with drug loading and yield values of 19.13% and 99.8%, respectively.     

Conclusion: The optimum formula with the highest response value is the formula containing 300 mg carbomer and 1000 mg ethyl cellulose.

Author Biographies

Lusia Oktora Ruma Kumala Sari, University of Jember, Jember, Indonesia

Faculty of Pharmacy

Lintang Qonita Fardliana, University of Jember, Jember, Indonesia

Faculty of Pharmacy

Dwi Nurahmanto, University of Jember, Jember, Indonesia

Faculty of Pharmacy

Eka Deddy Irawan, University of Jember, Jember, Indonesia

Faculty of Pharmacy

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Published

10-10-2023

How to Cite

Sari, L. O. R. K., Fardliana, L. Q., Nurahmanto, D., & Irawan, E. D. (2023). Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride. Pharmacy Education, 23(4), p. 27–31. https://doi.org/10.46542/pe.2023.234.2731

Issue

Vol. 23 No. 4 (2023): ICMHS Special Edition

Section

Special Edition

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