An observational analysis of blood and urine testosterone in diagnosis of polycystic ovarian syndrome

Authors

  • M.A. Hanny Ferry Fernanda Universitas Airlangga, Surabaya, Indonesia & Akademi Farmasi Surabaya, Surabaya, Indonesia https://orcid.org/0000-0002-0478-3685
  • Ashon Sa’adi Universitas Airlangga, Surabaya, Indonesia
  • Sudjarwo Universitas Airlangga, Surabaya, Indonesia

DOI:

https://doi.org/10.46542/pe.2023.234.259263

Keywords:

Diagnostic studies, ELISA method, Polycystic ovarian syndrome, Testosterone

Abstract

Background: An important diagnostic tool for the diagnosis of Polycystic ovarian syndrome (PCOS) in women is elevated blood testosterone levels. The presence of testosterone in the urine is very likely to support the PCOS diagnosis; however, more investigation is required to determine whether blood testosterone levels are associated with PCOS.

Objective: A total of 30 PCOS-positive women participated in this observational study using a diagnostic test approach.

Method: The ELISA technique was used to measure the amounts of testosterone in the woman's urine and serum.

Result: The levels of testosterone in the urine of 30 PCOS women were lower than those in the serum, with values of 2.688 nmol/L and 8.067 nmol/L, respectively. The Spearman correlation test findings revealed a value of 0.39 at a significance level of 0.05, with a cut-off value of 2.6010 nmol/L at sensitivity and specificity of 0.625 and 0.571, showing the importance of urine testosterone levels in detecting hyperandrogenic PCOS patients.

Conclusion: In women with PCOS, serum and urine testosterone levels are correlated.

Author Biographies

M.A. Hanny Ferry Fernanda, Universitas Airlangga, Surabaya, Indonesia & Akademi Farmasi Surabaya, Surabaya, Indonesia

Department Pharmaceutical Chemistry & Departement Pharmaceutical Chemistry

Ashon Sa’adi, Universitas Airlangga, Surabaya, Indonesia

Departement Obstetrics and Gynecology

Sudjarwo, Universitas Airlangga, Surabaya, Indonesia

Departement Pharmaceutical Chemistry

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Published

10-10-2023

How to Cite

Fernanda, M. H. F., Ashon Sa’adi, & Sudjarwo. (2023). An observational analysis of blood and urine testosterone in diagnosis of polycystic ovarian syndrome. Pharmacy Education, 23(4), p. 259–263. https://doi.org/10.46542/pe.2023.234.259263

Issue

Vol. 23 No. 4 (2023): ICMHS Special Edition

Section

Special Edition

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