Activities of sondhep herbs to cause changes in IL-1β in an osteoarthritis rat model

Authors

  • Retno Widyowati Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia & Natural Products Drug Discovery and Development Research Group, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia https://orcid.org/0000-0002-6166-1289
  • Iffatur Rosyidah Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia
  • Via Qurrota A’yun Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia
  • Rice Disi Oktarina Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia & Natural Products Drug Discovery and Development Research Group, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia
  • Irawati Sholikhah Faculty of Sains and Technology, Universitas Airlangga, Surabaya, Indonesia https://orcid.org/0000-0002-0124-8302
  • Ram Kumar Sahu Assam University, India

DOI:

https://doi.org/10.46542/pe.2023.234.228232

Keywords:

ELISA, IL-1β, MIA, Osteoarthritis, Sondhep

Abstract

Background: Osteoarthritis (OA) is a slowly progressive and degenerative joint disease. Symptoms of pain and inflammation are influenced by IL-1β, which increases COX-2 enzyme activity and PGE2 production. Sumenep Sondhep herbs are used by the community for joint pain.     

Objective: To evaluate the activities of the Sumenep Sondhep herb in reducing the cytokine IL-1β in the OA rats model.

Methods: Monosodium iodoacetate (MIA) induction was carried out on animal OA models. Rats were treated with Sondhep extract for 28 days. Knee diameter and hyperalgesia responses were recorded every week until the 7th week. The IL-1β levels were observed on the 21st and 49th days using the ELISA method.     

Results: There was a significant difference in decreasing the diameter of the rat's knee (p < 0.05), increasing the hyperalgesia test in the rats (p < 0.05), and decreasing IL-1β levels between before and after treatment (p < 0.05).       

Conclusion: The Sondhep Sumenep herb has activity against osteoarthritis by reducing pro-inflammatory cytokine IL-1β in OA rat models.

Author Biographies

Retno Widyowati, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia & Natural Products Drug Discovery and Development Research Group, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia

Department of Pharmaceutical Sciences

Iffatur Rosyidah, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia

Undergraduate Program

Via Qurrota A’yun, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia

Undergraduate Program

Rice Disi Oktarina, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia & Natural Products Drug Discovery and Development Research Group, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia

Department of Pharmaceutical Sciences

Irawati Sholikhah, Faculty of Sains and Technology, Universitas Airlangga, Surabaya, Indonesia

Department of Chemistry

Ram Kumar Sahu, Assam University, India

Department of Pharmaceutical Sciences

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Published

10-10-2023

How to Cite

Widyowati, R., Rosyidah, I., A’yun, V. Q., Oktarina, R. D., Sholikhah, I., & Sahu, R. K. (2023). Activities of sondhep herbs to cause changes in IL-1β in an osteoarthritis rat model. Pharmacy Education, 23(4), p. 228–232. https://doi.org/10.46542/pe.2023.234.228232

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