Activities of sondhep herbs to cause changes in IL-1β in an osteoarthritis rat model
DOI:
https://doi.org/10.46542/pe.2023.234.228232Keywords:
ELISA, IL-1β, MIA, Osteoarthritis, SondhepAbstract
Background: Osteoarthritis (OA) is a slowly progressive and degenerative joint disease. Symptoms of pain and inflammation are influenced by IL-1β, which increases COX-2 enzyme activity and PGE2 production. Sumenep Sondhep herbs are used by the community for joint pain.
Objective: To evaluate the activities of the Sumenep Sondhep herb in reducing the cytokine IL-1β in the OA rats model.
Methods: Monosodium iodoacetate (MIA) induction was carried out on animal OA models. Rats were treated with Sondhep extract for 28 days. Knee diameter and hyperalgesia responses were recorded every week until the 7th week. The IL-1β levels were observed on the 21st and 49th days using the ELISA method.
Results: There was a significant difference in decreasing the diameter of the rat's knee (p < 0.05), increasing the hyperalgesia test in the rats (p < 0.05), and decreasing IL-1β levels between before and after treatment (p < 0.05).
Conclusion: The Sondhep Sumenep herb has activity against osteoarthritis by reducing pro-inflammatory cytokine IL-1β in OA rat models.
References
Anggraini, O.D., Komariah, C., & Prasetyo, A. (2018). Effects of arumanis mango peel extract on reducing carrageenin-induced leg edema in male white mice. Journal of Health Library, 6(2), 267–271 https://doi.org/10.19184/pk.v6i2.7666
Badowska-Szalewska, E., Klejbor, I., Sidor-Kaczmarek, J., Cecot, T., Lietzau, G., Spodnik, J.H., & Moryś J. (2009). Stress-induced changes of interleukin-1β within the limbic system in the rat. Folia Morphological, 68(3), 119–128.
Bahrudin, M. (2018). Patofisiologi Nyeri (Pain). Saintika Medika, 13(1), 7 https://doi.org/10.22219/sm.v13i1.5449
Bao, Z., Chen, M., Li, C., Shan, Q., Wang, Y., & Yang, W. (2022). Monosodium iodoacetate–induced subchondral bone microstructure and inflammatory changes in an animal model of osteoarthritis. Open Life Science. 17(1), 781-793 https://doi.org/10.1515/bio-2022-0079
Goldring, M.B., & Otero, M. (2014). Inflammation in osteoarthritis. Curr Opin Rheumatol 23(5), 471–478 https://doi.org/10.1097/BOR.0b013e328349c2b1
Hadiwinata, A.P. (2016). Pemanfaatan jamu sondhep dan salekarang pada wanita pasca menopause keluarga Keraton Sumenep.
Harmita, H., Suryadi, H., & Likasa, D.L. (2020). Validation and analysis of diallyl disulfide and diallyl trisulfide in garlic (Allium sativum L.) using gas chromatograph. International Journal of Applied Pharmaceutics. 12(1),1–4 https://doi.org/10.22159/ijap.2020.v12s1.FF035
Heijink, A., Gomoll, H.A., Madry, H., Drobnic, M., Filardo G, Espregueira-Mendes J., & Van Dijk C.N. (2012). Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy, 20(3), 423–435 https://doi.org/10.1007/s00167-011-1818-0
Jabłońska-trypuć, A., Matejczyk, M. & Rosochacki, S. (2016). Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs enzymes in collagen degradation, as a target for anticancer drugs. Journal Enzyme Inhibitor Medicinal Chemistry, 31(1), 177-183 https://doi.org/10.3109/14756366.2016.1161620
Khotib, J., Pratiwi, A.P., Ardianto, C. & Rahmadi, M. (2020). Attenuation of IL-1124ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis. Journal of Basic and Clinical Physiology and Pharmacology, 30(6) https://doi.org/10.1515/jbcpp-2019-0332
Kiess, P.H., Dirsch, M.V., Hartung, T., Haffner, T., Trueman, L., Auger, J., Kahane, R. & Vollmar, A.M. (2003). Garlic (Allium sativum L.) Modulates Cytokine Expression in Lipopolysaccharide Activated Human Blood Thereby Inhibiting NF-kappaB activity. Journal of Nutrional. 133(7):2171-2175 https://doi.org/10.1093/jn/133.7.2171
Kim, W.K., Chung, J.H., Pyee, Y., Choi, J.T., Park H.J., Hong J.Y., Shin J.S., Lee, J.H., Ha, I.H. & Lee, S.K. (2016). Effects of intra-articular SHINBARO treatment on monosodium iodoacetate-induced esteoarthritis in rats. Chinese Medicine, 11(1), 1–10 https://doi.org/10.1186/s13020-016-0089-6
Li, J.Y., Wang, N.S., & Dong, M.Y. (2021). The effect of topical application of meloxicam on inflamed dental pulp. Journal of Dental Sciences, 16(3), 915–921 https://doi.org/10.1016/j.jds.2020.11.010
Mangestuti, Subehan, Widyawaruyanti, A., Zaidi, S.F.H., Awale, S., & Kadota, S. (2007). Traditional medicine of Madura island in Indonesia. Journal of Traditional Medicines, 24(3). https://doi.org/10.11339/jtm.24.90
Moilanen, L.J., Hamalainen, M., Nummenmaa, E., Ilmarinen, P., Vuolteenaho K., Nieminen R.M., Lehtimäki L., & Moilanen E. (2015). Monosodium iodoacetate induced inflammation and joint pain are reduced in TRPA1 deficient rat – Potential role of TRPA1 in osteoarthritis. Osteoarthritis and Cartilage, 23(11), 2017–2026 https://doi.org/10.1016/j.joca.2015.09.008
Oliveira, C.N., Alfieri, M.F. Lima, A.R.S., & Portes, A. (2019). Lifestyle and pain in women with knee osteoarthritis. American Journal of Lifestyle Medicine, 13(6), 606–610 https://dpi.org/10.1177/1559827617722112
Orita, S., Ishikawa, T., Miyagi, M., Ochiai, N., Inoue, G., Eguchi, Y., Kamoda, H., Arai, G., Toyone, T., Aoki, Y., Kubo, T., Takahashi, K., & Ohtori, S. (2011). Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain. BMC Musculoskeletal Disorders, 12(1), 1-12 https://doi.org/10.1186/1471-2474-12-134
Ren. K. & Torres, R. (2011). Role of interleukin-1β during pain and inflammation. Brain Res Rev, 60(1), 57–64 https://doi.org/10.1016/j.brainresrev.2008.12.020
Sari, R.A., Luthfiana, F., Sholihah, I., Matsunami, K., Sukardiman, & Widyowati R. (2023). Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis. Journal of Public Health in Africa, 14(S1), 2506 https://doi.org/10.4081/jphia.2023.2506
Siddik, M., & Haryadi, R. D. (2020). The risk factors effect of knee osteoarthritis towards postural lateral sway. Indian Journal of Forensic Medicine and Toxicology, 14(2), 1787–1792 https://doi.org/10.37506/ijfmt.v14i2.3196
Srikandi, S., Humaeroh, M., & Sutamirhadja, R.T.M. (2020). Kandungan gingerol dan shogaol dari ekstrak jahe merah (Zingiber officinale Roscoe) dengan metode maserasi bertingkat. Jurnal ilmu kimia & terapan, 7(2), 75–81 https://doi.org/10.15575/ak.v7i2.6545
Umar, I.M., Asmawi, Z.A., Sadikun, A., & Majid, S.M.A. (2014). Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions. CLINICS (Sao Paulo), 69(2), 134–144 https://doi.org/10.6061/clinics/2014(02)10
Widyowati, R., Suciati, S., Hariyadi, D.M., Chang, H., Ipg Suryawan N., Tarigan N., Sholikhah I., Ardianto C., Nurhan A.D., & Sagitaras I.B. (2023). The pro-inflammatory cytokine IL-Iβ alteration by deer (Rusa unicolor) antler extract on an osteoarthritis rat model. Saudi Pharmaceutical Journal. 31(6), 1109–1114 https://doi.org/10.1016/j.jsps.2023.03.022
Yoon, W.J., Lee, H.N., & Hyun, G.C. (2010). Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages. Journal of Oleo Science. 59(8), 415–421 https://doi.org/10.5650/jos.59.415