Terpenoids from Euphorbiaceae as a source of antimalarial medicines: A literature review
DOI:
https://doi.org/10.46542/pe.2023.234.294299Keywords:
Antimalarial, Euphorbiaceae, Plasmodium falciparum, TerpeneAbstract
Background: Malaria is an infectious disease caused by the Plasmodium parasite and transmitted by the Anopheles mosquito. Plasmodium falciparum is a parasite that causes the most deaths. Currently, there is resistance to various antimalarial drugs. For this reason, it is necessary to search for new antimalarial agents. Medicinal plants have been shown to play an important role in treating malaria for thousands of years. Some of Euphorbiaceae family plants contains terpenoid compounds, which are compounds with antimalarial activity.
Objective: The present review aims to provide an overview of the terpenoid compounds from Euphorbiaceae family as an antimalarial.
Method: Comprehensive information on Euphorbiaceae family from 2002-2022 was searched for literature relevant to major science-based data, including Scopus, Science, ScienceDirect, Pubmed, and SciFinder, using appropriate keyword combinations.
Result: A total of 15 papers were included in this review. The terpenoids isolated from 14 species of Euphorbiaceae family and reported to possess antimalarial activity are presented.
Conclusion: Terpenoids are found in almost all parts of Euphorbiaceae family plants and are reported to have moderate to high antimalarial activity. Screening of antimalarial terpenoid activity in Ephorbiaceae family plants can be a key step in the source and development of new antimalarial drugs.
References
Abdallah, I. I., & Quax, W. J. (2017). A Glimpse into the Biosynthesis of Terpenoids. KnE Life Sciences, 3(5), 81–98. https://doi.org/10.18502/kls.v3i5.981
Adelekan, A. M., Prozesky, E. A., Hussein, A. A., Ureña, L. D., van Rooyen, P. H., & Liles, D. C. (2008). Bioactive diterpenes and other constituents of Croton steenkampianus. Journal of Natural Products, 71(11), 1919–1922. https://doi.org/10.1021/np800333r
Attioua, B., Weniger, B., & Chabert, P. (2007). Antiplasmodial activity of constituents isolated from Croton lobatus. Pharmaceutical Biology, 45(4), 263–266. https://doi.org/10.1016/j.jep.2015.07.023
Banzouzi, J. T., Soh, P. N., Ramos, S., Toto, P., Cave, A., Hemez, J., et al. (2015). Samvisterin, a new natural antiplasmodial botulin derivative from Uapaca paludosa (Euphorbiaceae). Journal of Ethnopharmacology, 173, 100–104. https://doi.org/10.4269/ajtmh.16-0180
Bassat, Q., Velarde, M., Mueller, I., Lin, J., Leslie, T., Wongsrichanalai, C., et al. (2016). Key knowledge gaps for Plasmodium vivax control and elimination. The American Journal of Tropical Medicine and Hygiene, 95(6 Suppl), 62–71. https://doi.org/10.4269/ajtmh.16-0180
Bennett, B. C. (2011). Twenty-five economically important plant families. In B. C. Bennet (Ed.), Economic botany. Oxford, England: Encyclopedia of Life Support Systems. Retrieved from http://www.eolss.net/sample-chapters/c09/e6-118-03.pdf
Bero, J., Frédérich, M., & Quetin-Leclercq, J. (2009). Antimalarial compounds isolated from plants used in traditional medicine. The Journal of Pharmacy and Pharmacology, 61(11), 1401–1433. https://doi.org/10.1211/jpp.61.11.0001
Cos, P., Vlietinck, A. J., Berghe, D. V., & Maes, L. (2006). Anti-infective potential of natural products: How to develop a stronger in vitro 'proof-of-concept'. Journal of Ethnopharmacology, 106(3), 290–302. https://doi.org/10.1016/j.jep.2006.04.003
Gabriel, H. B., Sussmann, R. A. C., Kimura, E. A., Rodriguez, A. A. M., Verdaguer, I. B., Leite, G. C. F., et al. (2018). Terpenes as potential antimalarial drugs. In S. Perveen & A. Al-Taweel (Eds.), Terpenes and terpenoids (pp. 39-57). London, UK: IntechOpen.
Hadi, V., Hotard, M., Ling, T., Salinas, Y. G., Palacios, G., Connelly, M., et al. (2013). Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. European Journal of Medicinal Chemistry, 65, 376–380. https://doi.org/10.1016/j.ejmech.2013.04.030
Hamilton, A.C. (2004). Medicinal plants, conservation and livelihoods. Biodiversity and Conservation, 13, 1477–1517. https://doi.org/10.1023/B:BIOC.0000021333.23413.42
Katsuno, K., Burrows, J. N., Duncan, K., van Huijsduijnen, R. H., Kaneko, T., Kita, K., et al. (2015). Hit and lead criteria in drug discovery for infectious diseases of the developing world. Nature Reviews. Drug Discovery, 14(11), 751–758 https://doi.org/10.1038/nrd4683.
Köhler, I., Jenett-Siems, K., Siems, K., Hernández, M. A., Ibarra, R. A., & Berendsohn, W. G. (2002). In vitro antiplasmodial investigation of medicinal plants from El Salvador. Journal of Biosciences, 57(3-4), 277–281. https://doi.org/10.1515/znc-2002-3-413
Krettli, A. U., Adebayo, J. O., & Krettli, L. G. (2009). Testing of natural products and synthetic molecules aiming at new antimalarials. Current Drug Targets, 10(3), 261–270. https://doi.org/10.2174/138945009787581203
Langat, M. K., Crouch, N. R., Smith, P. J., & Mulholland, D. A. (2011). Cembranolides from the Leaves of Croton gratissimus. Journal of Natural Products, 74(11), 2349–2355 https://doi.org/10.1021/np2002012
Miller, L. H., Good, M. F., & Milon, G. (1994). Malaria pathogenesis. Science, 264(5167), 1878–1883. https://doi.org/10.1126/science.8009217
Ministry of Health Republic of Indonesia. (2014). Malaria management guidelines. Jakarta: Ministry of Health Republic of Indonesia
Mokgethi-Morule, T., & N'Da, D. D. (2016). Cell based assays for anti-Plasmodium activity evaluation. European Journal of Pharmaceutical Sciences, 84, 26–36. https://doi.org/10.1016/j.ejps.2016.01.001
Mongkolvisut, W., & Sutthivaiyakit, S. (2007). Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides. Journal of Natural Products, 70(9), 1434–1438. https://doi.org/10.1021/np070174v
Moore, D. V., & Lanier, J. E. (1961). Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine. The American Journal of Tropical Medicine and Hygiene, 10, 5–9. https://doi.org/10.4269/ajtmh.1961.10.5
Mota, M. L., Lobo, L. T., Costa, J. M., Costa, L. S., Rocha, H. A., Rocha e Silva, L. F., et al. (2012). In vitro and in vivo antimalarial activity of essential oils and chemical components from three medicinal plants found in north-eastern Brazil. Planta Medica, 78(7), 658–664. https://doi.org/10.1055/s-0031-1298333
Naing, C., Whittaker, M. A., Wai, N. V., & Mak, J. W. (2014). Is Plasmodium vivax malaria a severe malaria?: A systematic review and meta-analysis. PLoS Neglected Tropical Diseases, 8(8), e3071. https://doi.org/10.1055/s-0031-1298333
Namukobe, J., Kiremire, B. T., Byamukama, R., Kasenene, J. M., Akala, H. M., & Kamau, E. (2015). Antiplasmodial compounds from the stem bark of Neoboutonia macrocalyx pax. Journal of Ethnopharmacology, 162, 317–322. https://doi.org/10.1016/j.phytochem.2014.02.005
Namukobe, J., Kiremire, B. T., Byamukama, R., Kasenene, J. M., Dumontet, V., & Guéritte, F. (2014). Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L. Phytochemistry, 102, 189–196. https://doi.org/10.1016/j.jep.2014.12.018
Ndunda, B., Langat, M. K., Mulholland, D. A., Eastman, H., Jacob, M. R., & Khan, S. I.. (2016). New ent-clerodane and abietane diterpenoids from the roots of Kenyan Croton megalocarpoides Friis & M. G. Gilbert. Planta Medica, 82(11-12), 1079–1086. https://doi.org/10.1055/s-0042-108857
Rukunga, G., & Simons, A. J. (2006). The potential of plants as a source of antimalarial agents - A review. Berlin, Germany: PlantaPhile Publications
Saxena, S., Pant, N., Jain, D. C., & Bhakuni, R. S. (2003). Antimalarial agents from plant sources. Current Science, 85(9), 1314–1329.
Seephonkai, P., Sangdee, A., Bunchalee, P., & Pyne, S. G. (2009). Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx. Journal of Natural Products, 72(10), 1892–1894. https://doi.org/10.1021/np900352n
Shen, B. (2015). A new golden age of natural products drug discovery. Cell, 163(6), 1297–1300. https://doi.org/10.1016/j.cell.2015.11.031
Steele, J. C. P., Warhurst, D. C., Kirby, G. C., & Simmonds, M. S. J. (1999). In vitro and in vivo evaluation of betulinic acid as an antimalarial. Phytotherapy Research, 13(2), 115–119. https://doi.org/10.1002/(SICI)1099-1573(199903)13:2%3C115::AID-PTR404%3E3.0.CO;2-1
Sutthivaiyakit, S., Mongkolvisut, W., Prabpai, S., & Kongsaeree, P. (2009). Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima. Journal of Natural Products, 72(11), 2024–2027. https://doi.org/10.1021/np900342b
Thongtan, J., Kittakoop, P., Ruangrungsi, N., Saenboonrueng, J., & Thebtaranonth, Y. (2003). New antimycobacterial and antimalarial 8,9-secokaurane diterpenes from Croton kongensis. Journal of Natural Products, 66(6), 868–870. https://doi.org/10.1126/science.781840
Trager, W., & Jensen, J. B. (1976). Human malaria parasites in continuous culture. Science, 193(4254), 673–675. https://doi.org/10.1126/science.781840
Van Wyk, B.-E., van Oudtshoorn, B., & Gericke, N. (2009). Medicinal plants of South Africa (2nd ed.). Pretoria, South Africa: Briza Publications.
Widyawaruyanti, A., Devi, A. P., Fatria, N., Tumewu, L., Tantular, I. S., & Hafid, A. F. (2014). In vitro antimalarial activity screening of several Indonesian plants using HRP2 assay. International Journal of Pharmacy and Pharmaceutical Sciences, 6(6), 125–128. https://doi.org/10.30875/50d27d62-en
World Health Organisation. (2017). World malaria report 2017. Geneva: World Health Organisation. Accessed on https://www.who.int/publications/i/item/9789241565523
Zhou, B., Wu, Y., Dalal, S., Cassera, M. B., & Yue, J.-M. (2016). Euphorbesulins A–P, structurally diverse diterpenoids from Euphorbia esula. Journal of Natural Products, 79(8), 1952–1961. https://doi.org/10.1021/acs.jnatprod.6b00205