Assessment of the phytochemicals and anthelminthic activities of Adiantum raddianum and Kibatalia arborea extracts

Authors

  • Ghita Yogisuari University of Jember, Jember, Indonesia
  • Rocky Fahriar Reza UPT Laboratorium Herbal Materia Medica Batu, Malang, Indonesia
  • Lailia Nur Rachma Universitas Brawijaya, Malang, Indonesia & Maulana Malik Ibrahim State Islamic University, Malang, Indonesia
  • Tri Yudani Mardining Raras Universitas Brawijaya, Malang, Indonesia
  • Antonius Nugraha Widhi Pratama University of Jember, Jember, Indonesia https://orcid.org/0000-0001-9106-9924
  • Ari Satia Nugraha University of Jember, Jember, Indonesia https://orcid.org/0000-0002-9117-4713
  • Bawon Triatmoko University of Jember, Jember, Indonesia https://orcid.org/0000-0002-7963-9602

DOI:

https://doi.org/10.46542/pe.2023.234.284288

Keywords:

Caenorhabditis elegans, Jelutong pipit, Microdilution, Suplir, Thin layer chromatography

Abstract

Background: A limited spectrum and inappropriate use of anthelmintics lead to anthelmintic resistance. Among Indonesian medicinal plants, Adiantum raddianum (Suplir) and Kibatalia arborea (Jelutong Pipit) have shown antihelmintic properties.

Objective: To reveal the anthelmintic activity as preliminary screening of A. raddianum and K. arborea leaves.

Method: This study used the antihelmintic microdilution test towards methanol extracts at 500 µg/mL. The mortality of Caenorhabditis elegans expresses the presence of anthelmintic activity. Phytochemical screening was determined using thin-layer chromatography.

Result: The methanol extracts of both extracts had anthelmintic activity with mortality values of 14.941% and 15.134%, respectively. Both extracts contain polyphenols, flavonoids, terpenoids, and alkaloids found only in K. arborea. 

Conclusion: This study reveals that the methanol extract of A. raddianum and K. arborea leaves have anthelmintic activity, which could be related to the findings of phytochemical constituents.

Author Biographies

Ghita Yogisuari, University of Jember, Jember, Indonesia

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy

Lailia Nur Rachma, Universitas Brawijaya, Malang, Indonesia & Maulana Malik Ibrahim State Islamic University, Malang, Indonesia

Doctoral Program of Medical Science & Department of Microbiology, Faculty of Medical and Health Science

Tri Yudani Mardining Raras, Universitas Brawijaya, Malang, Indonesia

Department of Biochemistry and Molecular Biology, Faculty of Medicine

Antonius Nugraha Widhi Pratama, University of Jember, Jember, Indonesia

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy

Ari Satia Nugraha, University of Jember, Jember, Indonesia

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy

Bawon Triatmoko, University of Jember, Jember, Indonesia

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy

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Published

10-10-2023

How to Cite

Ghita Yogisuari, Rocky Fahriar Reza, Lailia Nur Rachma, Tri Yudani Mardining Raras, Antonius Nugraha Widhi Pratama, Ari Satia Nugraha, & Bawon Triatmoko. (2023). Assessment of the phytochemicals and anthelminthic activities of Adiantum raddianum and Kibatalia arborea extracts. Pharmacy Education, 23(4), p. 284–288. https://doi.org/10.46542/pe.2023.234.284288

Issue

Vol. 23 No. 4 (2023): ICMHS Special Edition

Section

Special Edition

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