Formulation, physicochemical characterisation, and in vitro evaluation of quercetin-alginate microsphere system

Authors

  • Dewi Melani Hariyadi Department of Pharmaceutical Sciences & Nanotechnology and Drug Delivery System Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Shafa Azaria Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Lintang Arum Cindravani Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia https://orcid.org/0009-0009-8113-4724
  • Annisa Dayu Syifa Ramadhani Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Yotomi Desia Eka Rani Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • I Nengah Budi Sumartha Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Ahmad Dzulfikri Nurhan Department of Pharmacy Practice & Biomedical Pharmacy Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Toetik Aryani Department of Pharmacy Practice & Biomedical Pharmacy Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Mahardian Rahmadi Department of Pharmacy Practice & Biomedical Pharmacy Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
  • Yashwant V Pathak USF Health Taneja College of Pharmacy, University of South Florida
  • Chrismawan Ardianto Department of Pharmacy Practice & Biomedical Pharmacy Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

DOI:

https://doi.org/10.46542/pe.2024.243.1924

Keywords:

Alginate, Microsphere, Quercetin

Abstract

Background: Quercetin exhibits various pharmacological properties. Unfortunately, quercetin has problems related to solubility, stability, and bioavailability, so it is necessary to develop an appropriate drug delivery system for quercetin.    

Objective: The study aims to develop a quercetin microsphere system and determine the effect of sodium alginate concentration on the physical characteristics and release of quercetin from the microspheres.    

Method: Quercetin-alginate microspheres were formed using sodium alginate with concentrations: Formula 1 (F1) 1%; Formula 2 (F2) 1.5%; Formula 3 (F3) 2% combined with 0.5 M CaCl2 using the ionotropic gelation and aerosolisation technique.

Results: The study found that the higher alginate concentration significantly increased microsphere particle size (6.53 – 8.34 µm) and decreased drug loading (11.58% - 6.08%). In addition, too low or high alginate concentrations accelerated the quercetin release. Variations of alginate concentration did not significantly affect the encapsulation efficiency, polydispersity index, and moisture content properties. The kinetic release of the microsphere followed the Higuchi kinetics model with the diffusion-controlled mechanism.    

Conclusion: This study successfully developed an alginate microsphere system controlling quercetin release. In addition, variations in sodium alginate concentration affect the particle size, drug loading, and cumulative release of quercetin from the alginate microsphere system.

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Published

01-05-2024

How to Cite

Hariyadi, D. M., Azaria, S., Cindravani, L. A., Ramadhani, A. D. S., Rani, Y. D. E., Sumartha, I. N. B., Nurhan, A. D., Aryani, T., Rahmadi, M., Pathak, Y. V., & Ardianto, C. (2024). Formulation, physicochemical characterisation, and in vitro evaluation of quercetin-alginate microsphere system. Pharmacy Education, 24(3), p. 19–24. https://doi.org/10.46542/pe.2024.243.1924

Issue

Vol. 24 No. 3 (2024): IGSCPS Special Edition

Section

Special Edition

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