Microemulsion technology: Nanoparticle-based emulsion as a sustainable natural product formulation

Authors

  • Mikael Ham Sembiring Faculty of Military Pharmacy, Indonesia Defense University, Sentul, Bogor, Indonesia
  • Arsyadi Faculty of Military Pharmacy, Indonesia Defense University, Sentul, Bogor, Indonesia
  • Taufik Riadi Faculty of Military Pharmacy, Indonesia Defense University, Sentul, Bogor, Indonesia

DOI:

https://doi.org/10.46542/pe.2024.246.124127

Keywords:

Essential oil, Microemulsion, Nanoparticle, Natural product, Sustainable technology

Abstract

Natural products refer to chemicals or compounds from living creatures occurring naturally in the environment. Natural commodities, such as spices, herbs, and medical remedies, are often used as additions. Natural products have many advantages, such as their environmentally sustainable nature, compatibility with the skin, affordability, and widespread availability. Nevertheless, developing natural products has several challenges, such as limited options for ingredients, functional limitations of natural substances, considerations about stability and preservation, consumer perceptions and expectations, and the variability in the composition of natural products. Microemulsions are prevalent emulsions that incorporate nanoparticles. A microemulsion is a homogeneous, transparent liquid consisting of oil, water, and a surfactant, often combined with a cosurfactant. The use of microemulsions has been extensively observed in many chemical and pharmacological applications owing to their unique attributes, such as a significant interfacial area, little interfacial tension, and the ability to solubilise and deliver hydrophobic substances. Therefore, the present review paper aims to comprehensively analyse microemulsion technology and its applications as an environmentally friendly formulation for natural products. Here, we propose strategies and research on microemulsions to overcome problems in natural product formulations.

References

Ait-Touchente, Z., Zine, N., Jaffrezic-Renault, N., Errachid, A., Lebaz, N., Fessi, H., & Elaissari, A. (2023). Exploring the versatility of microemulsions in cutaneous drug delivery: Opportunities and challenges. Nanomaterials, 13(10), 1688. https://doi.org/10.3390/nano13101688

Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., & Mnif, W. (2016). Essential oils’ chemical characterization and investigation of some biological activities: A critical review. Medicines, 3(4), 25. https://doi.org/10.3390/medicines3040025

Dávila-Rodríguez, M., López-Malo, A., Palou, E., Ramírez-Corona, N., & Jiménez-Munguía, M. T. (2020). Essential oils microemulsions prepared with high-frequency ultrasound: Physical properties and antimicrobial activity. Journal of Food Science and Technology, 57, 4133‒4142. https://doi.org/10.1007/s13197-020-04449-8

Danielsson, I., & Lindman, B. (1981) The definition of microemulsion. Colloids Surf., 3, 391–392. https://doi.org/10.1016/0166-6622(81)80064-9

Fadel, B. A., Elwakil, B. H., Fawzy, E. E., Shaaban, M. M., & Olama, Z. A. (2023). Nanoemulsion of Lavandula angustifolia essential oil/gold nanoparticles: Antibacterial effect against multidrug-resistant wound-causing bacteria. Molecules, 28(19), 6988. https://doi.org/10.3390/molecules28196988

Irshad, M., Subhani, M. A., Ali, S., & Hussain, A. (2020). Biological importance of essential oils. Essential Oils-Oils of Nature, 1, 37‒40. http://dx.doi.org/10.5772/intechopen.87198

Marinho, V. H., Neves, F. B., Jimenez, D. E., Oliveira, F. R., Santos, A. V. T., Ferreira, R. M., ... & Ferreira, I. M. (2022). Development of an environmentally friendly formulation of silk fibroin combined with fatty acid from Astrocaryum murumuru Mart. effective against Aedes aegypti larvae. Journal of Drug Delivery Science and Technology, 75, 103626. https://doi.org/10.1016/j.jddst.2022.103626

Martins, A. M., & Marto, J. M. (2023). A sustainable life cycle for cosmetics: From design and development to post-use phase. Sustainable Chemistry and Pharmacy, 35, 101178.

https://doi.org/10.1016/j.scp.2023.101178

Najmi, A., Javed, S. A., Al Bratty, M., & Alhazmi, H. A. (2022). Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents. Molecules, 27(2), 349. https://doi.org/10.3390/molecules27020349

Pavela, R., Benelli, G., Pavoni, L., Bonacucina, G., Cespi, M., Cianfaglione, K., ... & Maggi, F. (2019). Microemulsions for delivery of Apiaceae essential oils—Towards highly effective and eco-friendly mosquito larvicides? Industrial Crops and Products, 129, 631‒640. https://doi.org/10.1016/j.indcrop.2018.11.073

Racovita, R. C., Ciuca, M. D., Catana, D., Comanescu, C., & Ciocirlan, O. (2023). Microemulsions of nonionic surfactant with water and various homologous esters: Preparation, phase transitions, physical property measurements, and application for extraction of tricyclic antidepressant drugs from aqueous media. Nanomaterials, 13(16), 2311. https://doi.org/10.3390/nano13162311

Sharma, A., Dubey, S., & Iqbal, N. (2021). Microemulsion formulation of botanical oils as an efficient tool to provide sustainable agricultural pest management. Nano-and Microencapsulation-Techniques and Applications. IntechOpen. https://doi.org/10.5772/intechopen.91788

Souto, E. B., Cano, A., Martins-Gomes, C., Coutinho, T. E., Zielińska, A., & Silva, A. M. (2022). Microemulsions and nanoemulsions in skin drug delivery. Bioengineering, 9(4), 158. https://doi.org/10.3390/bioengineering9040158

Thakur, D., Kaur, G., Puri, A., & Nanda, R. (2021). Therapeutic potential of essential oil-based microemulsions: reviewing state-of-the-art. Current Drug Delivery, 18(9), 1218‒1233. https://doi.org/10.2174/1567201818666210217161240

Downloads

Published

14-06-2024

How to Cite

Sembiring, M. H., Arsyadi, & Riadi, T. (2024). Microemulsion technology: Nanoparticle-based emulsion as a sustainable natural product formulation. Pharmacy Education, 24(6), p. 124–127. https://doi.org/10.46542/pe.2024.246.124127