Effect ratio of stearic acid and oleic acid on characteristics of diclofenac sodium nanostructured lipid carrier
DOI:
https://doi.org/10.46542/pe.2024.243.336342Keywords:
Diclofenac sodium, Nanostructured lipid carrier, Oleic acid, Physicochemical characterisation, Stearic acidAbstract
Background: Osteoarthritis treatment generally involves using a Non-steroidal Anti-inflammatory Drug (NSAID), and the most common is Diclofenac sodium. The oral use of diclofenac sodium presents some adverse effects on the gastrointestinal tract. Trans-dermal diclofenac sodium's biological efficacy can be affected by factors including its log P value of 1.13. Nanostructured Lipid Carrier (NLC) may solve these concerns.
Objective: This study examined how stearic and oleic acid concentrations customise diclofenac sodium NLC's physicochemical properties.
Method: High shear homogenisation was used to compare stearic acid and oleic acid at 6:4, 7:3, and 8:2. Furthermore, the physicochemical properties of diclofenac sodium NLC were assessed, such as organoleptic, particle size and poly-dispersity index, pH, viscosity, zeta potential, entrapment efficiency, profiles of FTIR and DSC.
Result: This study found that particle size ranged from 333.60 ± 144.29 to 791.77 ± 85.57, and entrapment efficiency was 89.38 ± 3.69 to 76.96 ± 3.29. Increasing the content of oleic acid as a liquid lipid reduces particle size and improves diclofenac sodium NLC entrapment. According to One-Way ANOVA, the dependent variable was not significantly affected by any independent variables (p-value > 0.05) except for particle size and entrapment efficiency.
Conclusion: Stearic acid-oleic acid concentration ratios affect diclofenac sodium NLC's physicochemical properties.
References
Anggraeni, Y., & Hendradi, E. (2017). Physical and chemical characteristics of meloxicam from nanostructured lipid carriers system using some concentration ratios of monostreanin and alpha-tocopherolacetate lipid matrix. Asian Journal of Pharmaceutical and Clinical Research, 10(2), 132‒137. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.14806
Annisa, R., Hendradi, E., & Melani, D. (2016). Development of a meloxicam nanostructured lipid carrier (NLC) system with monostearin and miglyol 808 lipids using the emulsification method. Journal of Tropical Pharmacy and Chemistry, 3(3), 156‒169. http://dx.doi.org/10.25026/jtpc.v3i3.102
Avdeef, A., Berger, C. M., & Brownell, C. (2000). pH-metric solubility. 2: Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods. Pharmaceutical research, 17(1), 85‒89. https://doi.org/10.1023/a:1007526826979
Bawazeer, S., El-Telbany, D. F. A., Al-Sawahli, M. M., Zayed, G., Keed, A. A. A., Abdelaziz, A. E., & Abdel-Naby, D. H. (2020). Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats. Drug Delivery, 27(1), 1218‒1230. http://dx.doi.org/10.1080/10717544.2020.1803448
Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018). Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics, 10(2), 57. https://doi.org/10.3390/pharmaceutics10020057
Dantas, I. L., Bastos, K. T. S., Machado, M., Galvao, J. G., Lima, A. D., Gonsalves, J. K. M. C., Almeida, E. D. P., Araujo, A. A. S., Meneses, C. T. D., Sarmento, V. H. V., Nunes, R. S., & Lira, A. A. M. (2018). Influence of stearic acid and beeswax as solid lipid matrix of lipid nanoparticles containing tacrolimus. Journal of Thermal Analysis and Calorimetry, 132, 1557‒1566. http://dx.doi.org/10.1007/s10973-018-7072-7
de Souza Guedes, L., Martinez, R. M., Bou-Chacra, N. A., Velasco, M. V. R., Rosado, C., & Baby, A. R. (2021). An overview on topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles. Antioxidants, 10(7), 1034. http://dx.doi.org/10.3390/antiox10071034
Dietrich, T., Leeson, R., Gugliotta, B., & Petersen, B. (2014). Efficacy and safety of low dose subcutaneous diclofenac in the management of acute pain: A randomised double‐blind trial. Pain Practice, 14(4), 315-323. https://doi.org/10.1111/papr.12082
Fathi, H. A., Allam, A., Elsabahy, M., Fetih, G., & El-Badry, M. (2018). Nanostructured lipid carriers for improved oral delivery and prolonged antihyperlipidemic effect of simvastatin. Colloids and Surfaces B: Biointerfaces, 162, 236‒245. http://dx.doi.org/10.1016/j.colsurfb.2017.11.064
Hendradi, E., Hidayati, F. N., & Erawati, T. (2021). Characteristic of Nanostructured Lipid Carrier (NLC) diclofenac diethylammonium as function of ratio of glyceryl monostearate and caprylic acid. Research Journal of Pharmacy and Technology (RJPT), 14(3), 1699‒1704. http://dx.doi.org/10.5958/0974-360X.2021.00302.4
Hendradi, E., Rosita, N., & Rahmadhanniar, E. (2017). Effect of lipid ratio of stearic acid and oleic acid on characteristics of Nanostructure Lipid Carrier (NLC) system of diethylammonium diclofenac. Indonesian Journal of Pharmacy, 28(4), 198‒204. http://dx.doi.org/10.14499/indonesianjpharm28iss4pp198
Khater, D., Nsairat, H., Odeh, F., Saleh, M., Jaber, A., Alshaer, W., Bawab, A., & Mubarak, M. S. (2021). Design, preparation, and characterization of effective dermal and transdermal lipid nanoparticles: A review. Cosmetics, 8(2), 39. https://doi.org/10.3390/cosmetics8020039
Kon, Y., Ichikawa-Shigeta, Y., Iuchi, T., Nakajima, Y., Nakagami, G., Tabata, K., Sanada, H., & Sugama, J. (2017). Effects of a skin barrier cream on management of incontinence-associated dermatitis in older women: A cluster randomised controlled trial. Journal of Wound, Ostomy, and Continence Nursing, 44(5), 481–486. https://doi.org/10.1097/WON.0000000000000353
Luo, X., Zhou, Y., Bai, L., Liu, F., Deng, Y., & McClements, D. J. (2017). Fabrication of β-carotene nano-emulsion-based delivery systems using dual-channel micro fluidisation: Physical and chemical stability. Journal of colloid and interface science, 490, 328‒335. http://dx.doi.org/10.1016/j.jcis.2016.11.057
Nguyen, C.N., Nguyen, T.T.T., Nguyen, H.T., Tran, T.H. (2017). Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac. Drug Deliv. Transl. Res. 7(5), 664–673. http://dx.doi.org/10.1007/s13346-017-0415-2
Phatak, A. A., & Chaudhari, P. D. (2013). Development and evaluation of nanostructured lipid carrier (NLC) based topical delivery of an anti-inflammatory drug. Journal of pharmacy research, 7(8), 677‒685. http://dx.doi.org/10.1016/j.jopr.2013.08.020
Rao, M., Reddy, R. B., & Kumar, R. P. (2015). Formulation development and evaluation of Diclofenac sodium microemulsion. Indo American Journal of Pharmaceutical Sciences, 2(12), 1673-1688.
Salvi, V. R., & Pawar, P. (2019). Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier. Journal of Drug Delivery Science and Technology, 51, 255‒267. http://dx.doi.org/10.1016/j.jddst.2019.02.017
Shah, S. N. H., Ahmad, M., Badshah, A., Rabbani, M., & Salman, M. (2012). Effect of oleic acid on the permeation kinetics of Diclofenac Diethylamine. Journal of the Chemical Society of Pakistan, 34(6), 1.
Souto, E. B., Fangueiro, J. F., Fernandes, A. R., Cano, A., Sanchez-Lopez, E., Garcia, M. L., Severino, P., Paganelli, M. O., Chaud, M. V., & Silva, A. M. (2022). Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery. Heliyon, 8(2), e08938. https://doi.org/10.1016/j.heliyon.2022.e08938
