Antioxidant activity of Bougainvillea spectabilis ethanol extracts as an aryl hydrocarbon inhibitor
DOI:
https://doi.org/10.46542/pe.2024.243.395400Keywords:
Antioxidant, Bougainville spectabilis Willd, Ethanol extract, Molecular dockingAbstract
Background: Antioxidants overcome ageing processes and skin tissue damage caused by free radicals. The flavonoid contents of Bougainvillea spectabilis Willd contain hydroxyl groups attached to the carbon of the aromatic rings which makes them capable of catching free radicals and absorbing UV-A and UV-B.
Objective: This study aimed to investigate the in silico antioxidant activities of various compounds contained in B. spectabilis Willd ethanol extracts compared to control.
Method: The identification was carried out using GCMS methods and Molegro Virtual Docker. The molecular mechanics of scoring functions used in this study were the Rerank score, Root Mean Standard Deviation, and H Bond
Result: p-Trimethylsylyoxylphenyl-(trimethylsilyoxy)trimethylsilyacrilate had a better bond than vitamin C used as the control and is smaller than BHF_401 (A) standard ligand, indicated by rerank scores of -92.6478, -76.0593, and -104.771.
Conclusion: p-Trimethylsilyloxyphenyl-(trimethylsilyloxy)trimethylsilylacrylate had a better and more stable bond (rerank score: -92.6478) than the positive vitamin C control (76.0593).
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