ICOPMAP SPECIAL EDITION Phytochemistry and pharmacology of Pandanus amaryllfolius Roxb.
DOI:
https://doi.org/10.46542/pe.2025.252.95102Keywords:
Antibacterial, Anticancer, Antioxidant, Metabolic syndromeAbstract
Background: An interesting medicinal plant in Southeast Asia, Pandanus amaryllifolius Roxb. (P. amaryllifolius) is used as a flavouring and in Southeast Asian folk medicine to treat a range of illnesses.
Objective: An overview of research on the phytochemistry and pharmacological effects of P. amaryllifolius is the goal of this paper.
Method: This review was based on an analysis of scientific literature sourced from various electronic databases, including PubMed, ScienceDirect, Google Scholar, Web of Science, and Scopus.
Result: Pandamarilactonine-A and -B, pandanamine, pandamarilactone-1, and pandamarilactone-32 are among the primary chemical compounds extracted and identified from P. amaryllifolius. Norpandamarilactonines C and D, pandalizine C, pandalizine D, pandalizine E, pandanusine A, pandanusine B, and pandamarilactone-3. The potential pharmacological effects of P. amaryllifolius include hepatoprotective, antiviral, anticancer, antibacterial, and antihyperglycemic effects in the context of metabolic syndrome.
Conclusion: P. amaryllifolius may be used to treat various diseases; however, insufficient studies have been conducted on the phytochemistry of the plant. As a result, more research should concentrate on drug development, P. amaryllifolius leaf toxicity testing, and the isolation and identification of active compounds.
References
Cheng, Y. B., Hu, H. C., Tsai, Y. C., Chen, S. L., El-Shazly, M., Nonato, M. G., Wu, Y. C., &Chang, F. R. (2017). Isolation and absolute configuration determination of alkaloids from Pandanus amaryllifolius. Tetrahedron, 73(25), 3423–3429. https://doi.org/10.1016/j.tet.2017.05.002
Chiabchalard, A., & Nooron, N. (2015). Antihyperglycemic effects of Pandanus amaryllifolius Roxb. leaf extract. Pharmacognosy Magazine, 11(41), 117–122. https://doi.org/10.4103/0973-1296.149724
Chong, H. Z., Yeap, S. K., Rahmat, A., Akim, A. M., Alitheen, N. B., Othman, F., & Gwendoline-Ee, C. Ll. (2012). In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone-dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis. BMC Complementary and Alternative Medicine, 12, 134. https://doi.org/10.1186/1472-6882-12-134
Cooper, G. M. (2000). The development and causes of cancer. In The cell: A molecular approach. 2nd ed. Sunderland (MA): Sinauer Associates. https://www.ncbi.nlm.nih.gov/books/NBK9963/
Dhama, K., Latheef, S. K., Dadar, M., … , & Joshi, S. K. (2019). Biomarkers in stress-related diseases/disorders: Diagnostic, prognostic, and therapeutic values. Frontiers in Molecular Biosciences, 6(October), Article 91. https://doi.org/10.3389/fmolb.2019.00091
Doron, S., & Gorbach, S. L. (2008). Bacterial infections: Overview. International Encyclopedia of Public Health, 273–282. https://doi.org/10.1016/B978-012373960-5.00596-7
Engwa, G. A. (2018). Free radicals and the role of plant phytochemicals as antioxidants against oxidative stress-related diseases. In T. Asao & Md. Asaduzzaman (Eds.), Phytochemicals - Source of antioxidants and role in disease prevention. Intechopen. https://doi.org/10.5772/intechopen.76719
Gelderblom, H. R. (1996). Structure and classification of viruses. In Baron S. (Ed.), Medical microbiology. 4th ed. Galveston (TX): University of Texas Medical Branch at Galveston. https://www.ncbi.nlm.nih.gov/books/NBK8174/
Ghasemzadeh, A., & Jaafar, H. Z. (2013). Profiling of phenolic compounds and their antioxidant and anticancer activities in Pandanus amaryllifolius Roxb. extracts from different locations of Malaysia. BMC Complementary and Alternative Medicine, 13, Article 341. https://doi.org/10.1186/1472-6882-13-341
Giri, B., Dey, S., Das, T., Sarkar, M., Banerjee, J., & Dash, S. K. (2018). Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression, and other pathophysiological consequences: An update on glucose toxicity. Biomedicine and Pharmacotherapy, 107(July), 306–328. https://doi.org/10.1016/j.biopha.2018.07.157
Gopalkrishnan, B., Agashe, S., & Kumavat, U. (2015). Pharmacognostical screening of flavoring leaves Pandanus amaryllifolius Roxb. International Journal of Pharmacognosy and Phytochemical Research, 7(4), 745–749.
Hueh Zan, C., Rahmat, A., Abdah, Akim, Banu Mohd. Alitheen, N., Othman, F. and Ee Cheng Lian, G. (2011). Anti-proliferative effects of pandan leaves (Pandanus amaryllifolius), kantan flower (Etlingera elatior), and turmeric leaves (Curcuma longa). Nutrition and Food Science, 41(4), 238–241. https://doi.org/10.1108/00346651111151366
Jimtaisong, A., & Krisdaphong, P. (2013). Antioxidant activity of Pandanus amaryllifolius leaf and root extract and its application in topical emulsion. Tropical Journal of Pharmaceutical Research, 12(3), 425–431. https://doi.org/10.4314/tjpr.v12i3.23
Laluces, H. M. C., Nakayama, A., Nonato, M. G., & dela Cruz, T. E. (2015). Antimicrobial alkaloids from the leaves of Pandanus amaryllifolius. Journal of Applied Pharmaceutical Science, 5(10), 151–153. https://doi.org/10.7324/JAPS.2015.501026
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants, and functional foods: Impact on human health. Pharmacognosy Reviews, 4(8), 118–126. https://doi.org/10.4103/0973-7847.70902
Ooi, L. S. M., Sun, S. S. M., & Ooi, V. E. C. (2004). Purification and characterization of a new antiviral protein from the leaves of Pandanus amaryllifolius (Pandanaceae). International Journal of Biochemistry and Cell Biology, 36(8), 1440–1446. https://doi.org/10.1016/j.biocel.2004.01.015
Reshidan, N. H., Abd Muid, S., & Mamikutty, N. (2019). The effects of Pandanus amaryllifolius (Roxb.) leaf water extracts on fructose-induced metabolic syndrome rat model. BMC Complementary and Alternative Medicine, 19(1), Article 232. https://doi.org/10.1186/s12906-019-2627-0
Sanjeeva, Raveendra Kumar, N., Padmalaxmi, D., Ananthbabu, Udupa, A. L., Ojeh, N., Gupta, S., Rathnakar, U. P., Patil, V., Kodancha Prabhath, G., Benegal, D., Benegal, A., Rao, S. R., Nisarga, S., & Shubha, H. V. (2011). Antioxidant activity of methanol extract of Pandanus fascicularis Lam. Pharmacologyonline, 1(January), 833–841. https://researcher.manipal.edu/en/publications/antioxidant-activity-of-methanol-extract-of-pandanus-fascicularis
Swarup, S., Ahmed, I., Grigorova, Y., & Zeltser, R. (2024). Metabolic syndrome. In: StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK459248/
Sireeratawong, S., Chiranthanut, N., Lertprasertsuke, N., & Jaijoy, K. (2016). Acute and chronic toxicities of Pandanus amaryllifolius Roxb. water extract from the roots in rats. SOJ Pharmacy & Pharmaceutical Sciences, 3(2), 1-7. http://dx.doi.org/10.15226/2374-6866/3/2/00140
Takayama, H., Ichikawa, T., Kitajima, M., Aimi, N., Lopez, D., & Nonato, M. G. (2001). A new alkaloid, pandanamine; finding of an anticipated biogenetic intermediate in Pandanus amaryllifolius Roxb. Tetrahedron Letters, 42(16), 2995–2996. https://doi.org/10.1016/S0040-4039(01)00339-2
Takayama, H., Sudo, R., & Kitajima, M. (2005). Determination of absolute configuration of Pandanus alkaloid, pandamarilactonine-A, by first asymmetric total synthesis. Tetrahedron Letters, 46(35), 5795–5797. https://doi.org/10.1016/j.tetlet.2005.06.148
Thanebal, S. A. P., Vun-Sang, S., & Iqbal, M. (2021). Hepatoprotective effects of Pandanus amaryllifolius against carbon tetrachloride (CCl4) induced toxicity: A biochemical and histopathological study. Arabian Journal of Chemistry, 14(10), Article 103390. https://doi.org/10.1016/j.arabjc.2021.103390
Tsai, Y. C., Yu, M. L., El-Shazly, M., Beerhues, L., Cheng, Y. B., Chen, L. C., Hwang, T. L., Chen, H. F., Chung, Y. M., Hou, M. F., Wu, Y. C., & Chang, F. Rl. (2015). Alkaloids from Pandanus amaryllifolius: Isolation and their plausible biosynthetic formation. Journal of Natural Products, 78(10), 2346–2354. https://doi.org/10.1021/acs.jnatprod.5b00252
Wakte, K. V., Nadaf, A. B., Thengane, R. J., & Jawali, N. (2009). Pandanus amaryllifolius Roxb. cultivated as a spice in coastal regions of India. Genetic Resources and Crop Evolution, 56(5), 735–740. https://doi.org/10.1007/s10722-009-9431-5
