Modification of purple sweet potato starch (Ipomoea batatas L. Poir) with pragelatination and acetylation methods as disintegrant of paracetamol tablets
DOI:
https://doi.org/10.46542/pe.2023.232.207211Keywords:
Disintegrant, Purple sweet potato, Starch, TabletAbstract
Background: Starch of sweet potatoes is one of the ingredients that has many benefits, including in the pharmaceutical field, especially as a pharmaceutical excipient in pharmaceutical formulations. But it has poor flow properties.
Objective: The objective of the study is to isolate, characterise, modify and formulate the starch of Purple sweet potatoes (I. batatas L.Poir) into tablet dosage forms.
Method: purple sweet potato starch obtained from the isolation, then modified to improve its flow properties. Modifications made were by pregelatination and acetylation. after obtaining starch that meets the standards in the pharmacopoeia, then starch is used as a disintegrant in the formulation of paracetamol tablets with a concentration of 15%.
Result: The physicochemical characteristics of starch isolated from purple sweet potatoes are considered to meet the requirements of pharmaceutical excipients required in the Handbook of Pharmaceutical Excipients sixth edition and the United States Pharmacopeia 32nd edition.
Conclusion: The starch from purple sweet potato has the potential as an alternative disintegrant for tablet formulation, but the amount used needs to be reduced so as not to produce brittle tablets.
References
Anonim. (2007). The United States Pharmacopeia-National Formulary,Revision, Washington DC
Anonim., (2009)., USP 32: United States Pharmacopeia Convention, United States Pharmacopeia and the National Formulary (USP 32 - NF 27), The United States Pharmacopeial Convention, Rockville (MD)
Anonim., (2013). Farmakope Indonesia Edisi V. Jakarta: Kementrian Kesehatan RI
Azzahra, S. F (2019)., Metode Asetilasi-Oksidasi Dan Aplikasinya Sebagai Pengganti Gelatin Pada Marsmallow Cream. Indonesian Journal of Material Chemistry. 2 (1)
Azzahra, S. F. (2019). Modifikasi Pati Garut (Maranta Arundinacea) Dengan Metode Asetilasi-Oksidasi Dan Aplikasinya Sebagai Pengganti Gelatin Pada Marshmallow Cream. Indonesian Journal of Materials Chemistry, 2(1), 31–34. https://ejournal.uin-suka.ac.id/saintek/IJMC/article/view/2040/1710
Hidayat, B., N. Kalsum., dan Surfiana. (2009)., Perbaikan karakteristik tepung ubi kayu menggunakan metode pragelatinisasi parsial. Jurnal Teknologi Industri dan Hasil Pertanian. 14 (2): 148-159
Hu A., (2015). Ultrasonic FrequencyEffect on Corn Starch and ItsCavitation.Food Science andTechnology, 941- 947
Nurhayati, N. 2019. Modifikasi Pati Secara Asetilasi Pada Pembentukan Film.Jurnal Agrotek Ummat, 6(2), 100
Navarro, A., Martino, M., & Zaritzky, N. (1996). Modelling of rheological behaviour in starch–lipid systems. LWT-Food Science and Technology, 29(7), 632-639
Ohwoavworhua, F., Okhamafe, A. and Adelakun, T. (2009). Processing Pharmaceutical Grade Microcrystalline Cellulose from Groundnut Husk: Extraction and Characterisation, International Journal of Green Pharmacy, 3(2), pp. 97–104
Pawar, P.D. (2015). Review on Pharmaceutical Excipients. American Journal of Pharmacy &Health Research
Rendowaty A, Munarsih E&, Fizmawati. (2018)., Isolasi Pati Dari Tepung Ubi Jalar Ungu. Jurnal ilmiah bakti farmasi.;III(2)
Winanta, A., Syukri, Y., & Chabib, L. (2019). Formulasi tablet ekstrak buah naga (hylocereus polurhizus) menggunakan amilum ubi jalar pregelatinasi sebagai bahan penghancur. Medical sains: Jurnal Ilmiah Kefarmasian, 3(2), 105–118. http://ojs.stfmuhammadiyahcirebon.ac.id/index.php/iojs/article/view/56/69
Wulan, S. N., Widyaningsih, T. D., & Ekasari, D. (2007). Native and Debranched Starch Modification Using Physico-Chemical Treatment to Increase Resistant Starch Content in Rice. Jurnal Teknologi Pertanian, 8(2), 80–87. https://jtp.ub.ac.id/index.php/jtp/article/view/235
