Predicting factor analysis of gastrointestinal bleeding complication among hospitalised ischemic stroke patients

Authors

  • Fivy Kurniawati Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Erna Kristin Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Rizaldy T. Pinzon Universitas Gadjah Mada, Yogyakarta, Indonesia & Neurology Department, Bethesda Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0002-3357-9907
  • Sri Awalia Febriana Universitas Gadjah Mada, Yogyakarta, Indonesia

DOI:

https://doi.org/10.46542/pe.2023.232.139143

Keywords:

Antiplatelet, Gastrointestinal bleeding, Ischemic stroke, Predicting factor

Abstract

Background: Stroke is a common cardiovascular disease and the biggest cause of death and disability in the world. Treatment in affected patients aims to stabilise their condition and prevent further deterioration. One of the therapies in stroke patients is the administration of antiplatelet which may also cause adverse reactions in the form of gastrointestinal bleeding.

Objectives: This study aims to analyse the factors that can predict the emergence of gastrointestinal bleeding in hospitalised Ischemic stroke patients.     

Methods: A cohort study was conducted within a population of hospitalised patients diagnosed with Ischemic stroke. Patients' data from the hospital stroke registry was analysed. The significance of factors that can predict gastrointestinal bleeding incidence and the main predictor was determined.

Results: The results showed that out of the 96 patients included, 49 experienced gastrointestinal bleeding. Factors that had significant relationships with the incidence of gastrointestinal bleeding were symptoms of decreased consciousness with OR 9.03; 95% CI: 3.361 – 24.22, and loading dose OR 5.769; 95% CI: 1.191 – 27.941. In addition, the main predicting factor was symptoms of decreased consciousness with a p < 0.05 (<0.010), and OR value of 2.165 with 95% CI: 3.177 – 23.906.     

Conclusion: The occurrence of decreased consciousness can be a predictor of gastrointestinal bleeding.

Author Biographies

Fivy Kurniawati, Universitas Gadjah Mada, Yogyakarta, Indonesia

Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy & Doctorate Program of Medical and Health Science, Faculty of Medicine, Public Health and Nursing

Erna Kristin, Universitas Gadjah Mada, Yogyakarta, Indonesia

Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing

Rizaldy T. Pinzon, Universitas Gadjah Mada, Yogyakarta, Indonesia & Neurology Department, Bethesda Hospital, Yogyakarta, Indonesia

Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing

Sri Awalia Febriana, Universitas Gadjah Mada, Yogyakarta, Indonesia

Department Dermatology and Venereology, Faculty of Medicine Public Health and Nursing

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Published

15-05-2023

How to Cite

Kurniawati, F., Kristin, E., Pinzon, R. T., & Febriana, S. A. (2023). Predicting factor analysis of gastrointestinal bleeding complication among hospitalised ischemic stroke patients. Pharmacy Education, 23(2), p. 139–143. https://doi.org/10.46542/pe.2023.232.139143

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Special Edition