Assessment of healthcare students’ knowledge, attitudes, and perceptions towards pharmacogenomics at Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria
DOI:
https://doi.org/10.46542/pe.2024.241.718729Keywords:
Attitude, Healthcare student, Knowledge, Perception, PharmacogenomicsAbstract
Background: Pharmacogenomics explores how genetic variations affect drug responses, crucial for personalised medicine. Understanding healthcare students’ perspectives is vital for advancing awareness in this field. This study aimed to assess healthcare students’ knowledge, attitudes, and perceptions towards pharmacogenomics at Olabisi Onabanjo University, Sagamu Campus, Ogun State.
Methods: A cross-sectional survey was conducted among healthcare students (medicine, pharmacy, and nursing) at Olabisi Onabanjo University Teaching Hospital, Sagamu Campus, Ogun State, using purposive sampling.
Results: Respondents from medicine, nursing, and pharmacy demonstrated a moderate level of confidence in pharmacogenomics knowledge (38.1%, 75.9%, and 42.6%, respectively). They also indicated that their curricula inadequately cover pharmacogenomics (p < 0.001), highlighting the need for curriculum revisions to incorporate pharmacogenomics training.
Conclusion: Healthcare students exhibited fair knowledge and favourable attitudes towards pharmacogenomics, yet further education is essential for a comprehensive understanding of its fundamentals and clinical implications.
References
Abdela, O., Bhagavathula, A. S., Gebreyohannes, E. A., & Tegegn, H. (2017). Ethiopian health care professionals’ knowledge, attitude, and interests toward pharmacogenomics. Pharmacogenomics and Personalized Medicine, 10, 279–285. https://doi.org/10.2147/PGPM.S145336
Agrawal, M., Kirtania, L., Jha, A., & Hishikar, R. (2021). Students’ knowledge and views on pharmacogenomic education in the medical curriculum. Indian Journal of Pharmacology, 53(1), 19. https://doi.org/10.4103/ijp.IJP_495_19
AlEjielat, R., Ejielat, Z., Andrawes, S., & Mhaidat, N. M. (2016). An evaluation of the knowledge, opinions, expectations and concerns toward pharmacogenomics among Jordanian pharmacists. Personalized Medicine, 13(2), 143–154. https://doi.org/10.2217/pme.15.50
Coriolan, S., Arikawe, N., Moscati, A., Zhou, L., Dym, S., Donmez, S., Garba, A., Falbaum, S., Loewy, Z., Lull, M., Saad, M., Shtaynberg, J., & Obeng, A. O. (2019). Pharmacy students’ attitudes and perceptions toward pharmacogenomics education. American Journal of Health-System Pharmacy, 76(11), 836–845. https://doi.org/10.1093/ajhp/zxz060
Davies, S. M. (2006). Pharmacogenetics, pharmacogenomics and personalized medicine: Are we there yet? Hematology, 2006(1), 111–117. https://doi.org/10.1182/asheducation-2006.1.111
Giri, J., Curry, T. B., Formea, C. M., Nicholson, W. T., & Rohrer Vitek, C. R. (2018). Education and knowledge in pharmacogenomics: Still a challenge? Clinical Pharmacology & Therapeutics, 103(5), 752–755. https://doi.org/10.1002/cpt.1019
Goetz, L. H., & Schork, N. J. (2018). Personalized medicine: Motivation, challenges, and progress. Fertility and Sterility, 109(6), 952–963. https://doi.org/10.1016/j.fertnstert.2018.05.006
Hippman, C., & Nislow, C. (2019). Pharmacogenomic testing: Clinical evidence and implementation challenges. Journal of Personalized Medicine, 9(3), 40. https://doi.org/10.3390/jpm9030040
Hundertmark, M. E., Waring, S. C., Stenehjem, D. D., MacDonald, D. A., Sperl, D. D., Yapel, A., & Brown, J. T. (2020). Pharmacist’s attitudes and knowledge of pharmacogenomics and the factors that may predict future engagement. Pharmacy Practice, 18(3), 2008. https://doi.org/10.18549/PharmPract.2020.3.2008
Israt Khanom, N., Nur, S., Sabrina Mustari, S., Jamila, O., Sa A Dat, A., Hasan, M. M., Mahim, M., Faiza Bristy, F., Tamanna, N., Hossen, M. M., Kumar Das, S., Ahmed, T., Sapon, M. A., Islam, M. S., & Islam, M. M. (2023). Exploring the attitudes, beliefs and perceptions of undergraduate and graduate students in Bangladesh towards precision medicine and pharmacogenomics practice: A qualitative study. Personalized Medicine Journal, 8(29), 14–24. https://doi.org/10.22034/pmj.2023.705459
Karas Kuželički, N., Prodan Žitnik, I., Gurwitz, D., Llerena, A., Cascorbi, I., Siest, S., Simmaco, M., Ansari, M., Pazzagli, M., Di Resta, C., Brandslund, I., Schwab, M., Vermeersch, P., Lunshof, J. E., Dedoussis, G., Flordellis, C. S., Fuhr, U., Stingl, J. C., Van Schaik, R. H., … on behalf of the European Society of Pharmacogenomics and Personalized Therapy (ESPT). (2019). Pharmacogenomics education in medical and pharmacy schools: Conclusions of a global survey. Pharmacogenomics, 20(9), 643–657. https://doi.org/10.2217/pgs-2019-0009
Koutsilieri, S., Tzioufa, F., Sismanoglou, D.-C., & Patrinos, G. P. (2020). Unveiling the guidance heterogeneity for genome-informed drug treatment interventions among regulatory bodies and research consortia. Pharmacological Research, 153, 104590. https://doi.org/10.1016/j.phrs.2019.104590
Lee, M. T. M., & Klein, T. E. (2013). Pharmacogenetics of warfarin: Challenges and opportunities. Journal of Human Genetics, 58(6), 334–338. https://doi.org/10.1038/jhg.2013.40
Leong, S. L., Chaiyakunapruk, N., Tassaneeyakul, W., Arunmanakul, P., Nathisuwan, S., & Lee, S. W. H. (2019). Roles of pharmacogenomics in non-anthracycline antineoplastic-induced cardiovascular toxicities: A systematic review and meta-analysis of genotypes effect. International Journal of Cardiology, 280, 190–197. https://doi.org/10.1016/j.ijcard.2018.12.049
Lowitt, M. H., & Shear, N. H. (2001). Pharmacogenomics and dermatological therapeutics. Archives of Dermatology, 137(11), 1512–1514. https://doi.org/10.1001/archderm.137.11.1512
Luzzatto, L., & Seneca, E. (2014). G6 PD deficiency: A classic example of pharmacogenetics with on‐going clinical implications. British Journal of Haematology, 164(4), 469–480. https://doi.org/10.1111/bjh.12665
Mahmutovic, L., Akcesme, B., Durakovic, C., Akcesme, F. B., Maric, A., Adilovic, M., Hamad, N., Wjst, M., Feeney, O., & Semiz, S. (2018). Perceptions of students in health and molecular life sciences regarding pharmacogenomics and personalized medicine. Human Genomics, 12(1), 50. https://doi.org/10.1186/s40246-018-0182-2
Materials, U. (n.d.). How to calculate a reliable sample size using Taro Yamane method. Retrieved May 2, 2024, from https://www.academia.edu/33639897/HOW_TO_CALCULATE_A_RELAIBLE_SAMPLE_SIZE_USING_TARO_YAMANE_METHOD_docx
McCullough, K. B., Formea, C. M., Berg, K. D., Burzynski, J. A., Cunningham, J. L., Ou, N. N., Rudis, M. I., Stollings, J. L., & Nicholson, W. T. (2011). Assessment of the pharmacogenomics educational needs of pharmacists. American Journal of Pharmaceutical Education, 75(3), 51. https://doi.org/10.5688/ajpe75351
Mo, B. (2015). Demography and medical education among Nigerian final year medical students-implication for regional and human resource development. Journal of Health Education Research & Development, 3(3), 150. https://doi.org/10.4172/2380-5439.1000150
Muzoriana, N., Gavi, S., Nembaware, V., Dhoro, M., & Matimba, A. (2017). Knowledge, attitude, and perceptions of pharmacists and pharmacy students towards pharmacogenomics in Zimbabwe. Pharmacy (Basel, Switzerland), 5(4), 36. https://doi.org/10.3390/pharmacy5030036
Ogamba, C. F., Roberts, A. A., Ajudua, S. C., Akinwale, M. O., Jeje, F. M., Ibe, F. O., Afolayan, M. M., & Kuyinu, Y. A. (2023). Perceptions of Nigerian medical students regarding their preparedness for precision medicine: A cross-sectional survey in Lagos, Nigeria. BMC Medical Education, 23(1), 879. https://doi.org/10.1186/s12909-023-04841-w
Patel, S., Singh, R., Preuss, C. V., & Patel, N. (2024). Warfarin. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470313/
Rahma, A. T., Elsheik, M., Elbarazi, I., Ali, B. R., Patrinos, G. P., Kazim, M. A., Alfalasi, S. S., Ahmed, L. A., & Al Maskari, F. (2020). Knowledge and attitudes of medical and health science students in the United Arab Emirates toward genomic medicine and pharmacogenomics: A cross-sectional study. Journal of Personalized Medicine, 10(4), 191. https://doi.org/10.3390/jpm10040191
Siamoglou, S., Koromina, M., Moy, F.-M., Mitropoulou, C., Patrinos, G. P., & Vasileiou, K. (2021). What do students in pharmacy and medicine think about pharmacogenomics and personalized medicine education? Awareness, attitudes, and perceptions in Malaysian health sciences. OMICS: A Journal of Integrative Biology, 25(1), 52–59. https://doi.org/10.1089/omi.2020.0178
T P, A., M, S. S., Jose, A., Chandran, L., & Zachariah, S. M. (2009). Pharmacogenomics: The right drug to the right person. Journal of Clinical Medicine Research, 1(4), 191–194. https://doi.org/10.4021/jocmr2009.08.1255
Yau, A., Abd Aziz, A. B., & Haque, M. (2015). Knowledge, attitude and practice concerning pharmacogenomics among pharmacists: A systematic review. Journal of Young Pharmacists, 7(3), 145–154. https://doi.org/10.5530/jyp.2015.3.3
Zanger, U. M., & Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & Therapeutics, 138(1), 103–141. https://doi.org/10.1016/j.pharmthera.2012.12.007
Zayts, O., & Luo, Z. (2017). Commodification and marketisation of genetic testing through online direct-to-consumer platforms in Hong Kong. Discourse & Communication, 11(6), 630–647. https://doi.org/10.1177/1750481317726926